717915-17-8

Basic information

• Product Name: Ethanone, 1-[3,5-bis(1,1-dimethylethyl)phenyl]-2-bromo-
• CAS NO: 717915-17-8
• Molecular Formula: C16H23BrO
• Molecular Weight: 311.262
• Mol File: 717915-17-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-[3,5-bis(1,1-dimethylethyl)phenyl]-2-bromo-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-[3,5-bis(1,1-dimethylethyl)phenyl]-2-bromo-(717915-17-8)
• EPA Substance Registry System: Ethanone, 1-[3,5-bis(1,1-dimethylethyl)phenyl]-2-bromo-(717915-17-8)

Safety Data

• Hazardous Substances Data: 717915-17-8(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-[3,5-bis(1,1-dimethylethyl)phenyl]-2-bromo- is a chemical compound with the molecular formula C17H23BrO. It is a derivative of acetone with a bromine atom and a phenyl group substituted at the 1 and 2 positions, respectively. Ethanone, 1-[3,5-bis(1,1-dimethylethyl)phenyl]-2-bromo- is often used as an intermediate in organic synthesis and pharmaceutical research. It may also have potential applications in the development of new materials or as a reagent in chemical reactions. Additionally, it is important to handle and store this chemical with care, as it may be hazardous if not properly managed.

Upstream product

• 16225-26-6 3,5-di-tert-butylbenzoic acid 
• 1756-31-6 1-(3,5-di-tert-butylphenyl)ethanone 

Downstream Products

• 1351169-42-0 methyl 2-(3-{2-[2-(2-{2-[(S)-2-((2S,3R)-3-{[(9H-fluoren-9-yl)methoxy]carbonylamino}-2-hydroxy-4-phenylbutanamido)-4-methylpentanamido]ethoxy}ethoxy)ethoxy]acetamido}propoxy)-4-[(E)-3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]benzoate 
• 1351169-27-1 2-[3-(2-{2-[2-(2-{(S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanamido}ethoxy)ethoxy]ethoxy}acetamido)propoxy]-4-[(E)-3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid 
• 1351169-43-1 (S,E)-methyl 4-[3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]-2-(3-{2-[2-(2-{2-[4-methyl-2-(4-phenylbutanamido)pentanamido]ethoxy}ethoxy)ethoxy]acetamido}propoxy)benzoate 
• 1351169-28-2 (S,E)-4-[3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]-2-(3-{2-[2-(2-{2-[4-methyl-2-(4-phenylbutanamido)pentanamido]ethoxy}ethoxy)ethoxy]acetamido}propoxy)benzoic acid 
• 1351169-33-9 C₂₆H₃₂O₄ 
• 1351169-34-0 C₂₅H₃₁BrO₄ 
• 1351169-35-1 (E)-methyl 4-[3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]-2-hydroxybenzoate 
• 1351169-36-2 (E)-methyl 2-[3-(tert-butoxycarbonylamino)propoxy]-4-[3-(3,5-di-tert-butylphenyl)-3-oxoprop-1-enyl]benzoate 
• 1351169-37-3 (E)-methyl 2-(3-aminopropoxy)-4-[3-(3,5-di-tertbutylphenyl)-3-oxoprop-1-enyl]benzoate hydrochloride 
• 1351169-32-8 diethyl 3,5-di-tert-butylbenzoylmethylphosphonate 
• 1132879-25-4 9H-fluoren-9-ylmethyl {4-[4-(3,5-di-tert-butylphenyl)-1,3-thiazol-2-yl]tetrahydro-2H-pyran-4-yl}carbamate 
• 1135317-74-6 1-(3,5-di-tert-butylphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone 
• 1070176-35-0 C₂₇H₄₀N₂O₂S 
• 84217-89-0 3-(3,5-di-tert-butyl-4-hydroxyphenyl)-5,6-diphenyl imidazo[2,1-b]thiazole 

Relevant articles and documents

Design, synthesis and biological evaluation of nuclear receptor-degradation inducers

Compounds that regulate the function(s) of nuclear receptors (NRs) are useful for biological studies and as candidate therapeutic agents. Most such compounds are agonists or antagonists. On the other hand, we have developed specific protein degradation in

Inhibition of protein kinase C-driven nuclear factor-κB activation: Synthesis, structure-activity relationship, and pharmacological profiling of pathway specific benzimidazole probe molecules

A unique series of biologically active chemical probes that selectively inhibit NF-κB activation induced by protein kinase C (PKC) pathway activators have been identified through a cell-based phenotypic reporter gene assay. These 2-aminobenzimidazoles represent initial chemical tools to be used in gaining further understanding on the cellular mechanisms driven by B and T cell antigen receptors. Starting from the founding member of this chemical series 1a (notated in PubChem as CID-2858522), we report the chemical synthesis, SAR studies, and pharmacological profiling of this pathway-selective inhibitor of NF-κB activation.