113823-56-6Relevant articles and documents
Separation of enantiomers by extraction based on lipase-catalyzed enantiomer-selective fluorous-phase labeling
Hungerhoff, Benno,Sonnenschein, Helmut,Theil, Fritz
, p. 2492 - 2494 (2001)
No chromatography is necessary to separate a racemic alcohol into its enantiomers. A highly fluorinated acyl residue was tranferred in an enantiomer-selective manner onto a racemic alcohol in the presence of a lipase [Eq. (1)]. The labeled enantiomer was separated from the unlabeled one by a simple but very efficient partition between fluorous and organic phases.
Method for preparing supercritical carbon dioxide thickener for exploitation of extra-low permeability ultra-low permeability oil and gas reservoir
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Paragraph 0017; 0018; 0022; 0023; 0027; 0028, (2019/11/04)
The invention relates to a method for preparing a supercritical carbon dioxide thickener for exploitation of an extra-low permeability ultra-low permeability oil and gas reservoir, and aims to solve the problem that an oil and gas reservoir is damaged by a common exploitation mode. According to the technical scheme, the method comprises the following steps: putting a bottle into an ice water bath,adding perfluorooctyl ethanol, toluenesulfonyl chloride and pyridine, performing a reaction for three hours at 0-20 DEG C, adding filtering paper after the reaction is completed, performing ultrasonic dispersion for one hour, removing the filtering paper, and washing for 3-5 times with diluted hydrochloric acid so as to obtain an intermediate (1); putting (N-tert-butyloxy carbonyl) trihydroxymethyl aminomethane and the intermediate (1) into another bottle, adding potassium carbonate and N-N-dimethyl formamide, and heating to 60 DEG C to implement a reaction for four hours so as to obtain an intermediate (2); and finally adding trifluoroacetic acid, dichloromethane and the intermediate (2), performing a reaction for two hours at 50 DEG C, performing extraction and vacuum drying, adding 1,6-caproyl diisocyanate, and performing a reaction for two hours at 55 DEG C, thereby obtaining a final product. By adopting the thickener, the viscosity of carbon dioxide can be increased, and the thickener can be applied to fracturing transformation and chemical flooding.
Combining lipase-catalyzed enantiomer-selective acylation with fluorous phase labeling: A new method for the resolution of racemic alcohols
Hungerhoff, Benno,Sonnenschein, Helmut,Theil, Fritz
, p. 1781 - 1785 (2007/10/03)
Lipase-catalyzed acylation of racemic alcohols with a highly fluorinated acyl donor allows their kinetic resolution accompanied by the simultaneous enantiomer-selective fluorous phase labeling. Both the tagged and the untagged enantiomer can be separated without chromatography by a very efficient partition between a fluorous and an organic phase. The method has been successfully applied to the resolution of typically racemic secondary alcohols of low molecular weight. The fluorous label can be recovered quantitatively.