1139908-71-6

Basic information

• Product Name: (R)-(1,2,3,4-Tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester
• CAS NO: 1139908-71-6
• Molecular Weight: 219.283
• Mol File: 1139908-71-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-(1,2,3,4-Tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(1,2,3,4-Tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester(1139908-71-6)
• EPA Substance Registry System: (R)-(1,2,3,4-Tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester(1139908-71-6)

Safety Data

• Hazardous Substances Data: 1139908-71-6(Hazardous Substances Data)

Upstream product

• 109-21-7 butyl butyrate 
• 1424-84-6 1-(ethoxycarbonylmethyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Lipase-catalyzed kinetic resolution of 1,2,3,4-tetrahydroisoquinoline-1-acetic acid esters

The enantiomers of 1,2,3,4-tetrahydroisoquinoline- and 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-1-acetic acids were prepared via Burkholderia cepacia lipase (lipase PS-D)-catalyzed kinetic resolution of the corresponding ethyl and 2-methoxyethyl esters using enantioselective (E > 200) hydrolysis in DIPE. The (S)-acids were produced enzymatically, whereas the (R)-acids were obtained via the chemical hydrolysis of the unreacted (R)-esters. The solvent and its water content had major effects on both reactivity and enantioselectivity. The methoxyethyl moiety of the ester had a key role concerning the reactivity of the substrates.