1424-84-6

Basic information

• Product Name: ethyl 1,2,3,4-tetrahydroisoquinolin-1-ylacetate
• CAS NO: 1424-84-6
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.2796
• Mol File: 1424-84-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 327.5°C at 760 mmHg
• Flash Point: 151.9°C
• Density: 1.062g/cm³
• Vapor Pressure: 0.000201mmHg at 25°C
• Refractive Index: 1.514
• CAS DataBase Reference: ethyl 1,2,3,4-tetrahydroisoquinolin-1-ylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1,2,3,4-tetrahydroisoquinolin-1-ylacetate(1424-84-6)
• EPA Substance Registry System: ethyl 1,2,3,4-tetrahydroisoquinolin-1-ylacetate(1424-84-6)

Safety Data

• Hazardous Substances Data: 1424-84-6(Hazardous Substances Data)

Upstream product

• 4041-77-4 ethyl 3,4-dihydroisoquinoline-1-acetate 
• 64-04-0 phenethylamine 
• 140-88-5 ethyl acrylate 
• 22901-09-3 2-(2-bromoethyl)benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 622-24-2 2-phenylethyl chloride 
• 3230-65-7 3,4-dihydroisoquinoline 
• 1071-46-1 hydrogen ethyl malonate 

Downstream Products

• 1139908-70-5 C₁₅H₂₁NO₂ 
• 1139908-71-6 (R)-(1,2,3,4-Tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester 
• 288839-72-5 (S)-(1,2,3,4-Tetrahydro-isoquinolin-1-yl)-acetic acid ethyl ester 
• 734534-01-1 2-(2-iodobenzoyl)-1-[3-(trimethylsilyl)prop-2-ynyl]-3,4-dihydro-1H-isoquinoline 
• 70094-63-2 1,2,3,4,4a,6,7,13-octahydroisoquino<1,2-f>pyrido<2,1-b>pyrimidin-13-one 
• 70094-62-1 1,2,3,4,6,7,11b,12-octahydro-13H-isoquino<2,1-a><1,8>naphthylidin-13-one 
• 74414-16-7 1-(1,5-diaza-2,6-dioxocyclodecanyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Palladium-Catalyzed C(sp2)-H Olefination of Free Primary and Secondary 2-Phenylethylamines: Access to Tetrahydroisoquinolines

A rapid construction of THIQs by a Pd(II)-catalyzed C(sp2)-H olefination of free primary and secondary 2-phenylethylamines with high step- and atom-economy was reported. Notably, no substituent was required at the α-position to the amino group of the 2-phenylethylamines. The substrate scope was broad, and the reaction could also be applied to generate THIQs from the biologically active molecules such as the drug molecule baclofen and phenylalanine ester.

Eight-membered palladacycles derived from the insertion of olefins into the Pd-C bond of ortho-palladated pharmaceuticals phenethylamine and phentermine. Synthesis of stable heck-type intermediates containing accessible β-hydrogens and its use in the synt

The ortho-metalated complexes derived from phenethylamine and phentermine, [Pd(C,N-C6H4CH2CR2NH 2-2)(μ-X)]2 (R = H, X = Br (A); R = Me, X = Cl (B)), react with olefins giving (1) the produc

The Reaction of 3,4-Dihydroisoquinolines With Malonic Acid and Its Derivatives

The reaction of various 3,4-dihydroisoquinolines with malonic acid gives the corresponding 1,2,3,4-tetrahydro-1-isoquinolineacetic acids in good yield, while the reaction with cyanoacetic acid and malonic acid half ethyl ester affords 1,2,3,4-tetrahydro-1