114071-49-7Relevant articles and documents
New convergent synthesis of carbocyclic nucleoside analogues
Ludek, Olaf R.,Meier, Chris
, p. 2101 - 2109 (2007/10/03)
Two convergent approaches towards the synthesis of carbocyclic nucleoside analogs will be described. Both approaches start from the stereochemically pure cyclopentenol 8 that has been prepared enantioselectively from an alkylated cyclopentadiene. Using these approaches, carbocyclic analogues of dT, FdU and BVdU have been prepared. Moreover, the conversion into the cycloSalpronucleotide and the corresponding nucleotide will be presented for one example.
Hydroxymethyl (methylenecyclopentyl) purines and pyrimidines
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, (2008/06/13)
Antiviral activity is exhibited by compounds having the formula STR1 and its pharmaceutically acceptable salts.
Short Convergent Route to Homochiral Carbocyclic 2'-Deoxynucleosides and Carbocyclic Ribonucleosides
Biggadike, Keith,Borthwick, Alan D.,Exall, Anne M.,Kirk, Barrie E.,Roberts, Stanley M.,Youds, Peter
, p. 1083 - 1084 (2007/10/02)
The epoxide (1) has been converted into the antiviral agents (5) and (7) while epoxide (9) furnished carbocyclic guanosine (12).