648414-58-8

Basic information

• Product Name: 1-(3',5'-di-O-benzyl-2'-deoxy-6'-carba-β-D-ribofuranosyl)thymine
• Synonyms: 1-(3',5'-di-O-benzyl-2'-deoxy-6'-carba-β-D-ribofuranosyl)thymine
• CAS NO: 648414-58-8
• Molecular Weight: 420.508
• Mol File: 648414-58-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(3',5'-di-O-benzyl-2'-deoxy-6'-carba-β-D-ribofuranosyl)thymine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3',5'-di-O-benzyl-2'-deoxy-6'-carba-β-D-ribofuranosyl)thymine(648414-58-8)
• EPA Substance Registry System: 1-(3',5'-di-O-benzyl-2'-deoxy-6'-carba-β-D-ribofuranosyl)thymine(648414-58-8)

Safety Data

• Hazardous Substances Data: 648414-58-8(Hazardous Substances Data)

Upstream product

• 4330-20-5 N-3-benzoylthymine 
• 100-39-0 benzyl bromide 
• 1403561-77-2 (1R,3S,4R)-3-benzyloxy-4-(benzyloxymethyl)-1-tert-butyldimethylsilyloxycyclopentane 
• 1403561-76-1 (1S,2R,4R)-2-(benzyloxymethyl)-4-tert-butyldimethylsilyloxycyclopentanol 
• 1403561-75-0 (S)-3-(benzyloxymethyl)-1-tert-butyldimethylsilyloxycyclopent-3-en 
• 1417654-97-7 (S)-3-(benzyloxymethyl)cyclopent-3-enol 
• 1403561-38-5 (R)-3-(benzyloxymethyl)cyclopent-3-enyl acetate 
• 153186-83-5 (+/-)-3-[(benzyloxy)methyl]cyclopent-3-en-1-ol 
• 117641-39-1 (2R,3S)-2-benzyloxymethyl-6-oxabicyclo<3.1.0>hexan-3-ol 
• 542-92-7 cyclopenta-1,3-diene 
• 114071-49-7 1-(3',5'-di-O-benzyl-2'-deoxy-6'-hydroxy-6'-carba-β-D-ribofuranosyl)thymine 
• 39939-07-6 5-(benzyloxymethyl)cyclopentadiene 
• 3587-60-8 Benzyloxymethyl chloride 
• 648414-59-9 (1R,3S,4R)-3-(benzyloxy)-4-[(benzyloxy)methyl]cyclopentan-1-ol 

Downstream Products

• 114884-15-0 1-((1R,3S,4R)-3-hydroxy-4-(hydroxymethyl)cyclopentyl)-5-methylpyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

Synthesis of carbocyclic analogues of thymidine

A new route towards an enantiomerically pure carbocyclic 2′-deoxyribonucleoside precursor was developed. After coupling with a nucleobase the product is easily accessible for further modifications at the 3′-hydroxy group.

New convergent synthesis of carbocyclic nucleoside analogues

Two convergent approaches towards the synthesis of carbocyclic nucleoside analogs will be described. Both approaches start from the stereochemically pure cyclopentenol 8 that has been prepared enantioselectively from an alkylated cyclopentadiene. Using these approaches, carbocyclic analogues of dT, FdU and BVdU have been prepared. Moreover, the conversion into the cycloSalpronucleotide and the corresponding nucleotide will be presented for one example.