1146-43-6

Basic information

• Product Name: N-(m-hydroxyphenyl)-p-toluenesulphonamide
• Synonyms: N-(4-Hydroxyphenyl)-p-toluenesulphonamide; N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide; N-(3-hydroxyphenyl)-4-methylbenzenesulfonamide
• CAS NO: 1146-43-6
• Molecular Formula: C₁₃H₁₃NO₃S
• Molecular Weight: 263.3122
• EINECS: 214-550-6
• Mol File: 1146-43-6.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 446.9°C at 760 mmHg
• Flash Point: 224°C
• Density: 1.362g/cm³
• Vapor Pressure: 1.34E-08mmHg at 25°C
• Refractive Index: 1.645
• CAS DataBase Reference: N-(m-hydroxyphenyl)-p-toluenesulphonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(m-hydroxyphenyl)-p-toluenesulphonamide(1146-43-6)
• EPA Substance Registry System: N-(m-hydroxyphenyl)-p-toluenesulphonamide(1146-43-6)

Safety Data

• Hazardous Substances Data: 1146-43-6(Hazardous Substances Data)

Usage

General Description

N-(m-hydroxyphenyl)-p-toluenesulphonamide is a chemical compound that belongs to the class of organic compounds known as benzenesulfonyl compounds. Its molecular structure comprises a benzene ring attached to a sulfonyl group, with an additional hydroxyphenyl group. N-(m-hydroxyphenyl)-p-toluenesulphonamide is predominantly used in the field of chemistry for various experimental and research purposes. It may be synthesized through reactions involving m-aminophenol and toluenesulfonyl chloride. The properties of N-(m-hydroxyphenyl)-p-toluenesulphonamide, like its behavior, pH level, appearance or color, boiling and melting point, would require experimental testing for verification. It does not appear to have any pharmaceutical or industrial applications currently.

Upstream product

• 64-17-5 ethanol 
• 123-30-8 4-amino-phenol 
• 98-59-9 p-toluenesulfonyl chloride 
• 37051-70-0 4-methyl-N-(4-oxocyclohexa-2,5-dien-1-ylidene)benzenesulfonamide 
• 1150-26-1 N-(4-Methoxy-phenyl)-4-methyl-benzenesulfonamide 
• 51-78-5 p-aminophenol hydrochloride 
• 58750-86-0 N-(4-(benzyloxy)phenyl)-4-methylbenzenesulfonamide 
• 6373-46-2 p-benzyloxyaniline 
• 637-62-7 p-benzoquinone oxime 
• 108-95-2 phenol 
• 104-94-9 4-methoxy-aniline 
• 72973-25-2 N,N-dimethyl-1-(p-tolylsulfonyl)pyridin-1-ium-4-amine chloride 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 488-48-2 tetrabromobenzoquinone 
• 14504-09-7 2,3,5,5,6,6-hexachloro-2-cyclohexene-1,4-dione 
• 118-75-2 chloranil 
• 68374-97-0 N-p-methylbenzenesulfonyl-2,3,6-trichloro-1,4-benzoquinone imine 
• 120651-15-2 N-p-tolylsulfonyl-2,3,6-trichloro-4-aminophenol 
• 90264-13-4 2,6-dibromo-4-(p-tolylsulfonylamino)phenol 
• 107590-51-2 2,3,6-tribromo-4-(p-tolylsulfonylamino)phenol 
• 100073-66-3 N-p-methylbenzenesulfonyl-2,6-dibromo-1,4-benzoquinone imine 
• 141481-35-8 N-p-methylbenzenesulfonyl-2,3,5,6-tetrachloro-1,4-benzoquinone imine 
• 141481-39-2 2,3,5,6-tetrachloro-4-(4-methylphenylsulfonylamino)phenol 
• 141481-37-0 2,3,5,5,6,6-hexachloro-4-<(p-tolylsulfonyl)imino>-2-cyclohexen-1-one 
• 1351762-51-0 N-[4-(3-chlorobenzyloxy)phenyl]-4-methylbenzenesulfonamide 
• 1351762-53-2 N-[4-(3-methoxybenzyloxy)phenyl]-4-methylbenzenesulfonamide 
• 1351762-48-5 N-[4-(4-bromobenzyloxy)phenyl]-4-methylbenzenesulfonamide 

Relevant articles and documents

Synthesis of indole-fused scaffolds via [3+3] cyclization reaction of 2-indolylmethanols with quinone imines

A formal [3 + 3] cyclization reaction of 2-indolylmethanols with quinones was realized to furnish indole-fused scaffolds in moderate to excellent yields. This protocol was proceeded smoothly under acid condition, with high high yields and broad substrate scope.

Synthesis of Novel Pterocarpen Analogues via [3?+?2] Coupling-Elimination Cascade of α,α-Dicyanoolefins with Quinone Monoimines

By employing triethylamine as a catalyst, [3?+?2] coupling-elimination cascade of α,α-dicyanoolefins with quinone monoimines was realized. The reactions afforded various novel pterocarpen analogues with generally moderate yields (up to 75%). In addition, a plausible reaction mechanism was proposed.

Silver/Scandium-Cocatalyzed Bicyclization of β-Alkynyl Ketones Leading to Benzo[c]xanthenes and Naphtho[1,2-b]benzofurans

The combination of AgTFA and Sc(OTf)3 enables the bimetallic synergistic catalysis of β-alkynyl ketones and para-quinone methides (p-QMs), allowing direct synthesis of 17 examples of benzo[c]xanthenes with generally good yields through a benzannulation/1,6-addition/cyclization sequence. Exchanging p-QMs for quinone imine ketal resulted in 10 examples of tetracyclic naphtho[1,2-b]benzofurans via a similar benzannulation/1,4-addition/cyclization cascade. During these reaction processes, AgTFA and Sc(OTf)3 could be perfectly compatible, together with the realization of C(sp3)-H functionalization adjacent to carbonyl group on the β-alkynyl ketone unit.