114798-94-6 Usage
Description
Losartan Methyl Ether, also known as O-Methyl Losartan, is an impurity derived from Losartan (L470500), which is a nonpeptide angiotensin II AT1-receptor antagonist. It plays a significant role in the pharmaceutical industry due to its association with Losartan, a widely used antihypertensive medication.
Uses
Used in Pharmaceutical Industry:
Losartan Methyl Ether is used as an impurity in the production of Losartan, which is an essential antihypertensive agent. It helps in managing high blood pressure by blocking the action of angiotensin II, a hormone responsible for narrowing blood vessels. This action results in widened blood vessels and reduced blood pressure, making it a crucial component in the treatment of hypertension.
Additionally, as an impurity, Losartan Methyl Ether may also be involved in the research and development of new drugs or drug formulations, particularly those targeting the renin-angiotensin system for cardiovascular applications. Its presence in the manufacturing process of Losartan necessitates the need for quality control and purification techniques to ensure the safety and efficacy of the final drug product.
Check Digit Verification of cas no
The CAS Registry Mumber 114798-94-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,7,9 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 114798-94:
(8*1)+(7*1)+(6*4)+(5*7)+(4*9)+(3*8)+(2*9)+(1*4)=156
156 % 10 = 6
So 114798-94-6 is a valid CAS Registry Number.
114798-94-6Relevant articles and documents
[11C] Methyl-losartan as a potential ligand for PET imaging angiotensin II AT1 receptors
Hadizad, Tayebeh,Collins, Jeffrey,Antoun, Rawad E.,Beanlands, Rob S.,Dasilva, Jean N.
, p. 754 - 757 (2012/01/13)
The renin-angiotensin system regulates blood pressure via activation of the angiotensin II type 1 receptor (AT1R). The AT1R is involved in the pathology of cardiac and renal diseases such as heart failure and diabetic nephropathy. The aim of this study was to synthesize and characterize the O-[11 C]methylated derivative of the clinically used AT1 receptor blocker losartan as a novel AT1R PET imaging radioligand. [11 C]Methyl-losartan was reliably synthesized (n ≥ 40) via methylation of tetrazole-protected losartan followed by deprotection using HCl in an overall yield of 30%-60% (decay-corrected from [11 C]MeI). Radiochemical purity was >99% and specific activity 700-3600 mCi/μmol. Copyright 2011 John Wiley & Sons, Ltd. [11 C]Methyl-losartan has been synthesized in three steps: 1) protection of the tetrazole group, 2) [11 C]methylation of hydroxyl group, and 3) deprotection in acidic conditions. Copyright