114915-17-2 Usage
Description
7-Troc-paclitaxel, also known as 7-[(2,2,2,-Trichloroethyl)oxy]carbonyl Paclitaxel, is a chemical compound derived from paclitaxel, a widely used chemotherapeutic agent. It is characterized by the presence of a trichloroethyloxycarbonyl group at the C-7 position, which distinguishes it from its parent compound. This modification enhances its reactivity and utility in the synthesis of other taxane-based drugs.
Used in Pharmaceutical Industry:
7-Troc-paclitaxel is used as a reactant/reagent for the semisynthesis of Taxol (paclitaxel) and Docetaxel. It serves as a key intermediate in the direct esterification of deacetylbaccatin with the C13 side chain, allowing for the production of these important anti-cancer drugs.
Used in Anti-Tumor Agent Synthesis:
7-Troc-paclitaxel is also used as a reactant/reagent in the synthetic preparation and reaction of various anti-tumor agents. Its unique chemical structure makes it a valuable building block for the development of novel cancer therapies, potentially leading to more effective treatments with fewer side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 114915-17-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,9,1 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 114915-17:
(8*1)+(7*1)+(6*4)+(5*9)+(4*1)+(3*5)+(2*1)+(1*7)=112
112 % 10 = 2
So 114915-17-2 is a valid CAS Registry Number.
114915-17-2Relevant articles and documents
Improved protection and esterification of a precursor of the taxotere and taxol side chains
Commercon,Bezard,Bernard,Bourzat
, p. 5185 - 5188 (2007/10/02)
(4S,5R)-N-BOC-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylic acid 8 was prepared and efficiently esterified by conveniently protected baccatins 9a,b. Smooth deprotection in formic acid gave the N-deprotected intermediates of Taxotere and taxol. This protocol did not generate any epimerization at C-2′ and constitutes a pratical method to prepare Taxotere, taxol and analogs.