144787-20-2

Basic information

• Product Name: ETHYL 3-AZIDO-2-HYDROXY-PROPIONATE
• Synonyms: ETHYL 3-AZIDO-2-HYDROXY-PROPIONATE;(αR,βS)-β-Azido-α-hydroxybenzenepropanoic Acid Ethyl Ester
• CAS NO: 144787-20-2
• Molecular Formula: C₁₁H₁₃N₃O₃
• Molecular Weight: 159.14326
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 144787-20-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Solubility: Chloroform, Ethyl Acetate
• CAS DataBase Reference: ETHYL 3-AZIDO-2-HYDROXY-PROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 3-AZIDO-2-HYDROXY-PROPIONATE(144787-20-2)
• EPA Substance Registry System: ETHYL 3-AZIDO-2-HYDROXY-PROPIONATE(144787-20-2)

Safety Data

• Hazardous Substances Data: 144787-20-2(Hazardous Substances Data)

Usage

Description

ETHYL 3-AZIDO-2-HYDROXY-PROPIONATE, with the CAS number 144787-20-2, is a colorless oil compound that is primarily utilized in the field of organic synthesis. Its unique chemical structure and properties make it a valuable component in the creation of various organic compounds.

Uses

Used in Organic Synthesis:
ETHYL 3-AZIDO-2-HYDROXY-PROPIONATE is used as a synthetic building block for the development of new organic compounds. Its azido and hydroxy functional groups allow for a wide range of chemical reactions, making it a versatile starting material in the synthesis of various molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, ETHYL 3-AZIDO-2-HYDROXY-PROPIONATE is used as a key intermediate in the synthesis of pharmaceutical compounds. Its unique chemical properties enable the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
ETHYL 3-AZIDO-2-HYDROXY-PROPIONATE is also used as a research tool in chemical laboratories. Its reactivity and functional groups make it an ideal candidate for studying various chemical reactions and mechanisms, contributing to the advancement of chemical knowledge and the development of new synthetic methods.
Used in Material Science:
In the field of material science, ETHYL 3-AZIDO-2-HYDROXY-PROPIONATE can be used as a component in the development of new materials with specific properties. Its ability to participate in various chemical reactions allows for the creation of materials with tailored characteristics for different applications.

Upstream product

• 121-39-1 ethyl 3-phenylglycidate 
• 2272-55-1 (2R,3S)-ethyl 3-phenylglycidate 
• 121-39-1 ethyl cis-3-phenylglycidate 
• 144704-63-2 (4S,5R)-3-((2S,3R)-2-Bromo-3-hydroxy-3-phenyl-propionyl)-4-methyl-5-phenyl-oxazolidin-2-one 
• 100-52-7 benzaldehyde 
• 246861-66-5 ethyl (4S,5R)-4-carbethoxy-5-phenyl-1,3,2-dioxathiolane-2,2-dioxide 
• 4192-77-2 ethyl cinnamate 
• 172337-28-9 ethyl (4S,5R)-4-carbethoxy-5-phenyl-1,3,2-dioxathiolane-2-oxide 
• 108741-14-6 (2R,3S)-ethyl 2,3-dihydroxy-3-phenylpropanoate 
• 246861-67-6 ethyl (2S,3R)-3-bromo-2-hydroxy-3-phenylpropionate 
• 126060-73-9 ethyl (2R,3R)-3-phenyl-2,3-oxiranepropanoate 

Downstream Products

• 143615-00-3 (2R,3S)-3-amino-3-phenyl-2-hydroxypropionic acid ethyl ester 
• 143527-75-7 (2R,3S) ethyl N-(t-butoxycarbonyl)-3-phenylisoserine 
• 246861-68-7 ethyl (2R,3S)-3-azido-2-O-benzoyl-3-phenylpropionate 
• 143527-76-8 4-acetoxy-2α-benzoyloxy-5β,20-epoxy-1-hydroxy-9-oxo-7β,10β-bis[(2,2,2-tri-chloroethoxy)carbonyloxy]-11-taxen-13α-yl (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylate 
• 143527-73-5 C₅₁H₆₀Cl₃NO₁₇ 
• 143527-74-6 ethyl (4S,5R)-3-tert-butoxycarbonyl-2,2-dimethyl-4-phenyl-5-oxazolidinecarboxylate 
• 143615-03-6 (4S,5R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-4-phenyloxazolidine-5-carboxylic acid 
• 114915-14-9 7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)docetaxel 
• 114915-17-2 C₅₀H₅₂Cl₃NO₁₆ 
• 114915-15-0 C₄₃H₄₈Cl₃NO₁₅ 
• 33069-62-4 taxol 
• 114915-20-7 Docetaxel 
• 114915-16-1 10-deacetyl-7,10-diTroc-baccatin III 
• 153433-80-8 ethyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate 

Relevant articles and documents

Catalytic Asymmetric Epoxidation of Aldehydes with Two VANOL-Derived Chiral Borate Catalysts

A highly diastereo- and enantioselective method for the epoxidation of aldehydes with α-diazoacetamides has been developed with two different borate ester catalysts of VANOL. Both catalytic systems are general for aromatic, aliphatic, and acetylenic aldehydes, giving high yields and inductions for nearly all cases. One borate ester catalyst has two molecules of VANOL and the other only one VANOL. Catalysts generated from BINOL and VAPOL are ineffective catalysts. An application is shown for access to the side-chain of taxol.

Asymmetric epoxidation of cis-alkenes with arabinose-derived ketones: enantioselective synthesis of the side chain of Taxol

The ee values of asymmetric epoxidation of cis-ethyl cinnamate 15 with arabinose-derived ketones as catalyst and Oxone as the terminal oxidant were found to increase inversely with the size of the catalyst acetal blocking group. Ketone catalyst

Regio and stereoselective opening of chiral cyclic sulfates with MgBr2- Et2O : A practical strategy for the synthesis of (2R,3S)-(-)-N-benzoyl-3- phenylisoserine ethyl ester (taxol side chain)

The reaction of 4(S)-carbethoxy-5(R)-phenyl-1,3,2-dioxathiolane-2,2- dioxide 4 with MgBr2.Et2O readily proceed, regio- and stereoselectively at the benzylic position to afford the desired bromohydrin 5 in excellent yield which led to