115118-67-7

Basic information

• Product Name: diethyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate
• Synonyms: diethyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate
• CAS NO: 115118-67-7
• Molecular Weight: 260.287
• Mol File: 115118-67-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: diethyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate(115118-67-7)
• EPA Substance Registry System: diethyl 3,3-dimethoxycyclobutane-1,1-dicarboxylate(115118-67-7)

Safety Data

• Hazardous Substances Data: 115118-67-7(Hazardous Substances Data)

Upstream product

• 22094-18-4 1,3-dibromo-2,2-dimethoxypropane 
• 105-53-3 diethyl malonate 
• 153214-82-5 2,2-dimethoxypropane-1,3-diol 

Downstream Products

• 23761-23-1 3-oxocyclobutanecarboxylic acid 
• 130368-81-9 9-<3,3-bis(hydroxymethyl)cyclobut-1-yl>guanine 
• 131853-47-9 9-<3,3-bis(hydroxymethyl)cyclobut-1-yl>adenine 
• 131853-56-0 9-<3,3-bis(benzyloxymethyl)cyclobut-1-yl>guanine 
• 131853-55-9 2-amino-6-chloro-9-<3,3-bis(benzyloxymethyl)cyclobut-1-yl>-9H-purine 
• 131853-53-7 2,5-diamino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine 
• 131853-57-1 9-<3,3-bis(benzyloxymethyl)cyclobut-1-yl>adenine 
• 131853-54-8 6-chloro-9-<3,3-bis(benzyloxymethyl)cyclobut-1-yl>-9H-purine 
• 131853-52-6 5-amino-6-chloro-4-<<3,3-bis(benzyloxymethyl)cyclobut-1-yl>amino>pyrimidine 
• 131853-58-2 9-<3-benzyloxymethyl-3-hydroxymethylcyclobut-1-yl>adenine 
• 131853-51-5 3,3-bis(benzyloxymethyl)cyclobutanone oxime 
• 131853-49-1 3,3-dimethoxy-1,1-bis(benzyloxymethyl)cyclobutane 
• 131853-50-4 3,3-bis(benzyloxymethyl)cyclobutanone 
• 131853-48-0 1-amino-3,3-bis(benzyloxymethyl)cyclobutane 

Relevant articles and documents

Preparation method 3 - oxocyclobutane-based carboxylic acid

The invention discloses a preparation method of 3 -oxocyclobutane-based carboxylic acid, and belongs to the technical field of synthesis of medical intermediates. The ketone is protected from 1, 3 -dihydroxyacetone by condensation with trimethyl orthoformate to give 2, 2 -dimethoxy -1, 3 -propanediol, followed by reaction with malonate to give 3, 3 -dimethylcyclobutyl -1, 1 -dicarboxylic acid diester, followed by hydrolysis under acidic conditions. Decarboxylation and deprotection to yield 3 -oxocyclobutane-based carboxylic acids. The method has the advantages of high yield, common and easily available raw materials, simple flow and industrial amplification prospect.

Convenient Route to 1,3-Disubstituted Cyclobutanes: An Inexpensive Synthesis of 3-Oxocyclobutanecarboxylic Acid

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