115173-58-5

Basic information

• Product Name: C₂₁H₁₉⁽²⁾HN₂O₂S
• CAS NO: 115173-58-5
• Molecular Weight: 365.46
• Mol File: 115173-58-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₁₉⁽²⁾HN₂O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₁₉⁽²⁾HN₂O₂S(115173-58-5)
• EPA Substance Registry System: C₂₁H₁₉⁽²⁾HN₂O₂S(115173-58-5)

Safety Data

• Hazardous Substances Data: 115173-58-5(Hazardous Substances Data)

Upstream product

• 115173-56-3 2-(phenanthridin-6-ylmethyl)isoindoline-1,3-dione 
• 104970-12-9 phenanthridin-6-ylmethanamine 
• 29281-83-2 4-methylbenzensulphonamide potassium salt 
• 40484-36-4 6-(chloromethyl)phenanthridine 
• 113518-45-9 6-(p-tosylamidomethyl)phenanthridine 

Downstream Products

• 113518-44-8 C₂₂H₁₉⁽²⁾HN₂O₂S 

Relevant articles and documents

MODELS OF FOLATE COFACTORS 17. METHYLATION OF 1,3-DIMETHYL-6-METHYLAMINO-URACIL BY A 5,10-CH2-H4FOLATE MODEL. THE FIRST MIMIC OF THE OVERALL dTMP SYNTHASE REACTION

2-Tosyl-1,2,3,12b-tetrahydroimidazophenanthridine (6) was prepared in five steps from 6-chloromethylphenanthridine (1) in an overall yield of 50percent.The reaction of 6 with 1,3-dimethyl-6-methylaminouracil (8) in CH3CN/TFA (100:1) at 50-80 deg C, gave a mixture of products from which 1,3-dimethyl-6-methylaminothymine (9a) could be isolated.This constitutes a mimic of the overall dTMP synthase reaction in transferring both a methylene unit and a hydride equivalent from the cofactor model 6 to the 5-position of a uracil derivative.The other products which are formed in the reaction of 6 with 8 are derived from the reaction of the exocyclic intermediate C, formed in the carbon transfer step, with nucleophiles present in the reaction mixture.