115483-29-9Relevant articles and documents
Synthesis and biological evaluation of novel 3-O-tethered triazoles of diosgenin as potent antiproliferative agents
Masood-ur-Rahman,Mohammad, Younis,Fazili, Khalid Majid,Bhat, Khursheed Ahmad,Ara, Tabassum
, p. 1 - 8 (2017)
Diosgenin, a promising anticancer steroidal sapogenin, was isolated from Dioscorea deltoidea. Keeping its stereochemistry rich architecture intact, a scheme for the synthesis of novel diosgenin analogues was designed using Cu (I)-catalysed alkyne-azide cy
Synthetic modification of hydroxychavicol by Mannich reaction and alkyne-azide cycloaddition derivatives depicting cytotoxic potential
Kumar, Sunil,Pathania, Anoop S.,Satti, Naresh K.,Dutt, Parbhu,Sharma, Neha,Mallik, Fayaz A.,Ali, Asif
, p. 236 - 245 (2015)
Here we report the design, synthesis and lead optimization of hydroxychavicol (1) a high yielding metabolite ubiquitously present in the Piper betel leaves with the significant cytotoxic activity. This is the first report to describe the synthetic strateg
Synthesis of 3,4,5-trimethoxybenzene derivatives with substituted triazole group by Huisgen 1,3-cycloaddition and their inhibitory effects on 3T3-L1 adipocyte differentiation
Park, Sangkyu,Oh, Sangtae,Kim, Taejung,Ham, Jungyeob,Lee, Seokjoon
, p. 1364 - 1367 (2016)
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Synthesis of New Thieno[2,3-d]pyrimidines Containing a 1,2,3-Triazole Ring and Their Therapeutic Response in NCI-60 Cell Line Panel
Baluja, S. H.,Bhensdadia, K. A.,Lalavani, N. H.
, p. 1668 - 1677 (2021/12/13)
Abstract: A series of new tetrahydro[1]benzothieno[2,3-d]pyrimidines containing a 1,2,3-triazole fragment linkedthrough an oxymethylene spacer have been synthesized by click reaction of4-(prop-2-yn-1-yloxy)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidines with various aryl and alkyl azides inthe presence of copper sulfate and sodium ascorbate as a catalyst. Thestructures of the synthesized compounds were characterized by variousspectroscopic techniques (1H and13C NMR, FT-IR, and mass spectrometry), and theirin vitro anticancer activity against NCI-60 human tumor cell lines wasevaluated. Among the compounds tested, N-(pyridine-3-yl)-acetamide derivative exhibited significantactivity against several cancer cell lines, including SF-539 (CNS cancer),HCT-116 (colon cancer), OVCAR-8 (ovarian cancer), PC-3 (prostate cancer), andCCRF-CEM (leukemia).
Regioselective synthesis of 4-fluoro-1,5-disubstituted-1,2,3-triazoles from synthetic surrogates of α-fluoroalkynes
Jana, Sampad,Adhikari, Sweta,Cox, Michael R.,Roy, Sudeshna
supporting information, p. 1871 - 1874 (2020/02/20)
α-Fluoroalkynes are elusive molecules due to their instability and inaccessibility. Here, we show that α-fluoronitroalkenes can serve as synthetic surrogates of α-fluoroalkynes in [3+2] cycloaddition reactions with organic azides facilitated by a catalytic amount of trifluoroacetic acid (TFA). This work provides the first regioselective method to access 4-fluoro-1,5-disubstituted-1,2,3-triazoles.