24313-88-0Relevant articles and documents
New Syntheses of 3-Indolylglyoxal
Vereshchagin, A. L.,Bryanskii, O. V.,Semenov, A. A.
, p. 40 - 42 (1983)
In a study of the possibilities of a simple method for the preparation of 3-indolylglyoxals two new methods for the synthesis of indolylglyoxal structures were proposed.The first method consists in oxidation of 3-hydroxyacetylindole with the dimethyl sulfoxide - oxalyl chloride complex, but for a number of reasons it is virtually inapplicable to the preparation of substituted indolylglyoxals.In the second case the readily synthesized 3-indolylglyoxyl chlorides are reduced to the corresponding aldehydes in good yields by means of trialkyltin hydrides.
Room-temperature copper-catalyzed electrophilic amination of arylcadmium iodides with ketoximes
Korkmaz, Adem
, p. 3119 - 3125 (2021/05/10)
We started our study by preparation two ketoximes. Later, there were studies to reveal these ketoximes' effects in the electrophilic amination reaction with organocadmium reagents. Primarily, it was observed that arylcadmium iodides could not be reacted with ketoximes at room temperature in the absence of a catalyst. CuCN was a suitable catalyst for this electrophilic amination reaction of arylcadmium iodides and allowed the preparation of functionalized aniline derivatives in good yields under mild reaction conditions. We obtained the results indicated that the yield of primary arylamines was strongly dependent on the steric and electronic effects of organocadmium reagent and amination agent. In the case of both amination reagents, meta-substituted arylamines were obtained in higher yields than para-substituted arylamines. We observed that acetone O-(4-chlorophenylsulfonyl)oxime, 1, as an aminating agent, was more successful than acetone O-(2-Naphthylsulfonyl)oxime, 2, in the synthesis of functionalized arylamines by electrophilic amination of corresponding aryl cadmium iodides. In this method, there is no cadmium release to the environment.
Chemoselective reduction of nitroarenes with hydrazine over a highly active alumina-supported cobalt nanocatalyst
Albadi, Jalal,Samimi, Heshmat Allah,Jalali, Mehdi
, p. 740 - 744 (2019/10/14)
A green and efficient procedure is reported for the chemoselective reduction of nitroarenes catalyzed by a highly active alumina-supported cobalt nanocatalyst in the presence of hydrazine hydrate. The nanocatalyst can be applied under mild reflux conditions for the synthesis of arlyamines in high yields. Moreover, the catalyst can be easily recovered by simple filtration and reused several times without obvious loss in its catalytic activity.
A circulating aqueous phase system method of synthesizing aromatic primary amine
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Paragraph 0043; 0044, (2016/10/20)
The invention discloses a method for synthesizing an aromatic primary amine in a circulating water phase system. According to the method, an aryl halide and ammonia water are taken as raw materials, water is taken as a solvent, a carbonate, a fluoride, a phosphate or a hydroxide of an alkali metal or an alkaline-earth metal or a compound which can be converted to a corresponding alkali in water is taken as the alkali, polyamine carboxylic acid and a salt type compound thereof are taken as ligands, and a copper source catalyst is adopted for catalyzing the formation of the aromatic primary amine from the aryl halide and the ammonia water. According to the method disclosed by the invention, the water is used as the solvent, any phase transfer of the catalyst is not required, and the catalyst, the ligands and the reaction solvent, namely the water, can be recycled, so that the environment-friendly property of reaction is effectively improved, the method is more in line with requirements of green chemical development, a substrate particularly has a wide range of applications, and the method further has broad prospects in the aspects of preparation of natural products, medicaments and pesticides.
