123685-57-4Relevant articles and documents
6-Substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents
Gangjee,Vasudevan,Queener,Kisliuk
, p. 1778 - 1785 (1995)
The synthesis and biological activity of 15 6-substituted 2,4-diamino-5- methylpyrido[2,3-d]-pyrimidines are reported. These compounds were synthesized in improved yields by modifications of procedures previously reported by us. Specifically, dimethoxyphe
Synthesis and evaluation of novel fluorinated pyrazolo-1,2,3-triazole hybrids as antimycobacterial agents
Emmadi, Narender Reddy,Bingi, Chiranjeevi,Kotapalli, Sudha Sravanti,Ummanni, Ramesh,Nanubolu, Jagadeesh Babu,Atmakur, Krishnaiah
supporting information, p. 2918 - 2922 (2015/06/22)
A library of novel 3-trifluoromethyl pyrazolo-1,2,3-triazole hybrids (5-7) were accomplished starting from 5-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-amine (1) via key intermediate 2-azido-N-(5-phenyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)acetamide (3) throu
Potent inhibition of thymidylate synthase by two series of nonclassical quinazolines
McNamara,Berman,Fry,Werbel
, p. 2045 - 2051 (2007/10/02)
The synthesis and biological activity of two series of nonclassical thymidylate synthase (TS) inhibitors are described. The first is a series of 10-propargyl-5.8-dideazafolic acid derivatives (10a-j) and the second is a series of the analogous 2-desamino