65051-18-5Relevant articles and documents
Design and synthesis of novel substituted indole-acrylamide derivatives and evaluation of their anti-cancer activity as potential tubulin-targeting agents
Baytas, Sultan Nacak,Cetin-Atalay, Rengul,Ergun, Sezen Guntekin,Hamel, Ernest,Hawash, Mohammed,Kahraman, Deniz Cansen,Olgac, Abdurrahman
, (2022/01/19)
Novel compounds containing polar and nonpolar substitutions on the prop-2-en-1-on linker of the trans-indol-3-ylacrylamide scaffold were designed by modeling within the colchicine site of tubulin and then synthesized to determine the role of such substitu