1158183-68-6

Basic information

• Product Name: C₂₂H₁₂N₂O₂
• Synonyms: C₂₂H₁₂N₂O₂
• CAS NO: 1158183-68-6
• Molecular Weight: 336.349
• Mol File: 1158183-68-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₁₂N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₁₂N₂O₂(1158183-68-6)
• EPA Substance Registry System: C₂₂H₁₂N₂O₂(1158183-68-6)

Safety Data

• Hazardous Substances Data: 1158183-68-6(Hazardous Substances Data)

Upstream product

• 1158183-77-7 5-(p-tolyloxy)acenaphthenequinone 
• 109-77-3 malononitrile 

Downstream Products

• 1158183-49-3 3-(p-tolyloxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile 
• 1158183-52-8 4-(p-methylphenoxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile 

Relevant articles and documents

ACENAPHTHO HETEROCYCLE COMPOUNDS, CYCLODEXTRIN INCLUSION COMPOUNDS AND COMPLEXES, AND USES IN THE MANUFACTURES OF BH3 PROTEIN ANALOGUE, BCL-2 FAMILY PROTEIN INHIBITORS THEREOF

The present invention relates to acenaphtho heterocyclic compounds, cyclodextrin inclusion compounds and complexes thereof, and their uses in manufacturing the inhibitors of BH3 analogue, Bcl-2 family proteins. The acenaphtho heterocyclic compounds are obtained by introducing oxo-, thio-, carbonyl, ester or acyl in the 3-, 4- and 6-position of 8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile, or further substituting 9-cyano with carboxyl, ester or amide. The compounds can simulate BH3-only protein, competitively binding and antagonizing Bcl-2, Bcl-XL and Mcl-1 proteins in vitro or intracellularly, to induce cell apoptosis. The cyclodextrin inclusion compounds and complexes can improve the effects. Therefore, they can all be used in the manufacture of anticancer compounds.