1158183-49-3

Basic information

• Product Name: 3-(p-tolyloxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile
• Synonyms: 3-(p-tolyloxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile
• CAS NO: 1158183-49-3
• Molecular Weight: 336.349
• Mol File: 1158183-49-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(p-tolyloxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(p-tolyloxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile(1158183-49-3)
• EPA Substance Registry System: 3-(p-tolyloxy)-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile(1158183-49-3)

Safety Data

• Hazardous Substances Data: 1158183-49-3(Hazardous Substances Data)

Upstream product

• 1158183-77-7 5-(p-tolyloxy)acenaphthenequinone 
• 1158183-67-5 2-[2-oxo-2H-6-(p-tolyloxy)acenaphthylen-1-ylidene]-malononitrile 
• 1158183-68-6 C₂₂H₁₂N₂O₂ 
• 846038-96-8 8-oxo-8H-acenaphthyleno[1,2-b]pyrrole-9-carbonitrile 
• 106-44-5 p-cresol 
• 82-86-0 acenaphthene quinone 
• 26254-35-3 5-bromoacenaphthylene-1,2-dione 

Relevant articles and documents

ACENAPHTHO HETEROCYCLE COMPOUNDS, CYCLODEXTRIN INCLUSION COMPOUNDS AND COMPLEXES, AND USES IN THE MANUFACTURES OF BH3 PROTEIN ANALOGUE, BCL-2 FAMILY PROTEIN INHIBITORS THEREOF

The present invention relates to acenaphtho heterocyclic compounds, cyclodextrin inclusion compounds and complexes thereof, and their uses in manufacturing the inhibitors of BH3 analogue, Bcl-2 family proteins. The acenaphtho heterocyclic compounds are ob

3-Thiomorpholin-8-oxo-8 h -acenaphtho[1,2- b ]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): Structure-based design and structure-activity relationship studies

We recently described the discovery of a dual inhibitor of Bcl-2 and Mcl-1, 3-thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (3, S1). Here we report a structure-guided design in combination with structure-activity relationship studies to exploit the difference in the p2 binding pocket of Bcl-2 and Mcl-1, from which a novel dual inhibitor 3-(4-aminophenylthio)-8-oxo-8H- acenaphtho[1,2-b]pyrrole-9-carbonitrile (6h) was obtained, which showed significant enhanced IC50 value against Mcl-1 (5 nM), greater Mcl-1/Bak disruption potential, and accordingly a 10-fold increased cytotoxicity over 3.