1158999-45-1

Basic information

• Product Name: 5-chloro-2-(phenylthio)benzo[d]oxazole
• Synonyms: 5-chloro-2-(phenylthio)benzo[d]oxazole
• CAS NO: 1158999-45-1
• Molecular Weight: 261.732
• Mol File: 1158999-45-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-(phenylthio)benzo[d]oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-(phenylthio)benzo[d]oxazole(1158999-45-1)
• EPA Substance Registry System: 5-chloro-2-(phenylthio)benzo[d]oxazole(1158999-45-1)

Safety Data

• Hazardous Substances Data: 1158999-45-1(Hazardous Substances Data)

Upstream product

• 22876-19-3 5-chloro-2-mercaptobenzoxazole 
• 591-50-4 iodobenzene 
• 108-98-5 thiophenol 
• 59919-11-8 2-methyl-1-phenyl-2-(phenylthio)propan-1-one 
• 17200-29-2 5-chloro-benzoxazole 
• 882-33-7 diphenyldisulfane 

Relevant articles and documents

Copper(I)-Catalyzed Tandem One-Pot Synthesis of 2-Arylthiobenzothiazoles and 2-Arylthiobenzoxazoles in Water

An efficient tandem process for the preparation of 2-arylthiobenzothiazoles has been developed. By condensation of 2-aminobenzenethiol with tetramethylthiuram disulfide (TMTD), 2-mercaptobenzothiazoles was in situ generated, which susequently underwent coupling with iodobenzenes to give the desired 2-arylthiobenzothiazoles fluently in a one-pot manner. This method can also be used for the synthesis of 2-arylthiobenzoxazoles. Inexpensive metal catalyst and ligand, mild reaction temperature, and water as solvent make this protocol practically valuable and useful in organic synthesis.

Copper-catalyzed direct thiolation of benzoxazole with diaryl disulfides and aryl thiols

The cross-coupling reaction of benzoxazole with aryl thiols using the CuI/2,2′-bipyridine complex as a catalyst in DMF at 80 °C under oxygen produced the corresponding aryl thioethers in moderate to good yields. The coupling reaction with diaryl disulfide