1160723-52-3

Basic information

• Product Name: N-benzyl-N-((4-chlorophenyl)ethynyl)-4-methylbenzenesulfonamide
• Synonyms: N-benzyl-N-((4-chlorophenyl)ethynyl)-4-methylbenzenesulfonamide
• CAS NO: 1160723-52-3
• Molecular Weight: 395.909
• Mol File: 1160723-52-3.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: N-benzyl-N-((4-chlorophenyl)ethynyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-N-((4-chlorophenyl)ethynyl)-4-methylbenzenesulfonamide(1160723-52-3)
• EPA Substance Registry System: N-benzyl-N-((4-chlorophenyl)ethynyl)-4-methylbenzenesulfonamide(1160723-52-3)

Safety Data

• Hazardous Substances Data: 1160723-52-3(Hazardous Substances Data)

Upstream product

• 609769-63-3 N-benzyl-N-(p-toluenesulfonyl)-2-phenylethynylamine 
• 1617518-96-3 (Z)-N-benzyl-N-[2-phenyl-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)ethenyl]-4-methylbenzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 100-46-9 benzylamine 
• 873-73-4 4-n-chlorophenylacetylene 
• 1576-37-0 N-benzyl-p-toluenesulfonamide 
• 77295-59-1 1-chloro-4-(2,2-dibromovinyl)benzene 
• 33491-03-1 1-(bromoethynyl)-4-chlorobenzene 

Downstream Products

• 1645293-12-4 C₂₈H₁₈ClN₅O₂S 

Relevant articles and documents

Enantioselective Rhodium-Catalyzed Hydrogenation of (Z)-N-Sulfonyl-α-dehydroamido Boronic Esters

Highly enantioselective rhodium-catalyzed hydrogenation of (Z)-N-sulfonyl-α-dehydroamido boronic esters is realized for the first time using a JosiPhos-type ligand. This method has enabled convenient synthesis of a series of enantio-enriched N-sulfonyl-α-amido boronic esters in good yields and excellent enantioselectivities (up to 99% ee).

Synthesis of dihydro-[1,3]oxazino[4,3-a] isoindole and tetrahydroisoquinoline through Cu(OTf)2-catalyzed reactions of N-acyliminium ions with ynamides

An efficient approach to access functionalized dihydro-[1,3]oxazino[4,3-a] isoindole and tetrahydroisoquinoline skeletons has been developed through the addition-cyclization process of ynamides 8 with N-acyliminium ions generated from N,O-acetals 6,7. The reactions were conducted under the catalysis of Cu(OTf)2, and a number of functionalized dihydro-[1,3]oxazino[4,3-a] isoindoles 9a-9y and tetrahydroisoquinolines 10a-10g, 11a-11p were generated in 48–98% yields. When chiral ynamides 8n-8u were used, optically pure products 11a-11p could be obtained with good to excellent yields and diastereoselectivities.

Er(OTf)3-catalyzed approach to 3-alkenylindoles through regioselective addition of ynamides and indoles

An efficient approach to access functionalized 3-alkenylindoles has been developed through Er(OTf)3-catalyzed addition of ynamides and indoles. A number of C-aryl substituted ynamides 7a-7k could react with indoles 6a-6s, affording the desired products 8aa-8sa, 8ab-8ak, 8bd, 8bk and 8tc in moderate to excellent yields with high regioselectivities.