33491-03-1

Basic information

• Product Name: 1-(bromoethynyl)-4-chlorobenzene
• Synonyms: 1-(bromoethynyl)-4-chlorobenzene
• CAS NO: 33491-03-1
• Molecular Weight: 215.477
• Mol File: 33491-03-1.mol
• Article Data: 59

Chemical Properties

• CAS DataBase Reference: 1-(bromoethynyl)-4-chlorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(bromoethynyl)-4-chlorobenzene(33491-03-1)
• EPA Substance Registry System: 1-(bromoethynyl)-4-chlorobenzene(33491-03-1)

Safety Data

• Hazardous Substances Data: 33491-03-1(Hazardous Substances Data)

Upstream product

• 873-73-4 4-n-chlorophenylacetylene 
• 50650-48-1 1-ethynyl-4-chloro-benzene; mercury (II)-compound 
• 3201-63-6 -triphenyl-phosphoran 
• 77295-59-1 1-chloro-4-(2,2-dibromovinyl)benzene 
• 81559-60-6 1-Chloro-4-(2,2,2-tribromo-ethyl)-benzene 
• 3240-10-6 (4-chlorophenyl)propiolic acid 
• 622-95-7 4-chlorobenzyl bromide 
• 78704-49-1 1-(4-chlorophenyl)-2-trimethylsilylacetylene 
• 1777-56-6 4-chlorobenzoylmethylenetriphenylphosphorane 
• 104-88-1 4-chlorobenzaldehyde 

Downstream Products

• 934001-84-0 ClC₆H₄C₆H₁₁O₂C₃NOBr 
• 91585-33-0 ((4-Chlorophenyl)ethynyl)(phenyl)selane 
• 1315277-28-1 9-bromo-10-(4-chlorophenyl)bicyclo[6.2.0]dec-9-ene 
• 1426841-40-8 1-((4-chlorophenyl)ethynyl)cyclohexanecarbonitrile 
• 1426841-23-7 4-(4-chlorophenyl)-2,2-dimethylbut-3-ynenitrile 
• 1426841-39-5 4-(4-chlorophenyl)-2-ethyl-2-methylbut-3-ynenitrile 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 1519058-79-7 2-[(4-chlorophenyl)ethynyl]tetrahydrofuran 
• 873-73-4 4-n-chlorophenylacetylene 
• 1420041-14-0 1-((Z)-2-bromo-1-fluorovinyl)-4-chlorobenzene 
• 51624-43-2 1-[4-(4-chlorophenyl)butane-1,3-diynyl]benzene 
• 34966-48-8 ethyl 2-(4-chlorophenyl)-2-oxoacetate 

Relevant articles and documents

Regio- and Stereoselective N-addition to an Open Bromo Vinyl Cation

A protocol for the synthesis of thus far inaccessible bromo vinyl triflimides is presented. Our previously reported concept of assisted vinyl cation formation was engaged to achieve both a protonation of relatively electron poor bromo alkynes and a reaction with high regio- and stereoselectivity. To the best of our knowledge, this is the first stereoselective addition of an N-nucleophile to an open β-halovinyl cation.

Copper-Catalyzed Perfluoroalkylation of Alkynyl Bromides and Terminal Alkynes

A copper-catalyzed one-pot perfluoroalkylation of alkynyl bromides and terminal alkynes has been disclosed, and the corresponding perfluoroalkylated alkynes could be attained in good to excellent yields. The new straightforward transformation shows high efficiency (0.01-0.5 mol % catalyst loading), broad substrate scope, and remarkable functional group tolerance and provides a facile approach for useful application in life and material sciences.

Palladium-Catalyzed Carbonylation in the Synthesis of N-Ynonylsulfoximines

Palladium-catalyzed carbonylation reactions with Cr(CO)6 as carbonyl source are key for the preparation of N-ynonylsulfoximines from NH-sulfoximines and bromoalkynes. The couplings proceed at room temperature with a wide range of substrate combinations affording the corresponding products in good yields. (Figure presented.).