51624-43-2

Basic information

• Product Name: Benzene, 1-chloro-4-(4-phenyl-1,3-butadiynyl)-
• CAS NO: 51624-43-2
• Molecular Formula: C16H9Cl
• Molecular Weight: 236.7
• Mol File: 51624-43-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Benzene, 1-chloro-4-(4-phenyl-1,3-butadiynyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-chloro-4-(4-phenyl-1,3-butadiynyl)-(51624-43-2)
• EPA Substance Registry System: Benzene, 1-chloro-4-(4-phenyl-1,3-butadiynyl)-(51624-43-2)

Safety Data

• Hazardous Substances Data: 51624-43-2(Hazardous Substances Data)

Upstream product

• 932-87-6 1-Bromo-2-phenylacetylene 
• 33491-03-1 1-(bromoethynyl)-4-chlorobenzene 
• 5075-59-2 diethyl(phenylethynyl)aluminum 
• 873-73-4 4-n-chlorophenylacetylene 
• 536-74-3 phenylacetylene 
• 1430234-50-6 1-(4-chlorophenyl)-5-phenylpenta-1,4-diyn-3-one 
• 66482-30-2 (Z)-1-bromo-2-(4-chlorophenyl)ethylene 
• 33491-02-0 1-chloro-4-(chloroethynyl)benzene 
• 2170-06-1 1-Phenyl-2-(trimethylsilyl)acetylene 
• 104-88-1 4-chlorobenzaldehyde 
• 105836-22-4 trans-(2,3-dibromo-3-phenyl-2-propen-1-yl)triphenylphosphonium bromide 
• 118616-07-2 ((E)-2,3-Dibromo-3-phenyl-allyl)-triphenyl-phosphonium; bromide 

Relevant articles and documents

Controllable chemoselectivity in the coupling of bromoalkynes with alcohols under visible-light irradiation without additives: Synthesis of propargyl alcohols and α-ketoesters

The chemoselectivity of visible-light-induced coupling reactions of bromoalkynes with alcohols can be controlled by simple changes to the reaction atmosphere (N2 or O2). A N2 atmosphere favours propargyl alcohols via a direct C-C coupling process, whereas an O2 atmosphere results in the generation of α-ketoesters through the oxidative CC/C-O coupling pathway.

Gold-Catalyzed Cadiot–Chodkiewicz-type Cross-Coupling of Terminal Alkynes with Alkynyl Hypervalent Iodine Reagents: Highly Selective Synthesis of Unsymmetrical 1,3-Diynes

A new and efficient method for the synthesis of unsymmetrical 1,3-butadiynes by gold-catalyzed C(sp)–C(sp) cross-coupling of terminal alkynes with alkynyl hypervalent iodine(III) reagents has been developed. The reaction features high selectivity and efficiency, mild reaction conditions, wide substrate scope, and functional-group compatibility, and is a highly attractive complement to existing methods. Mechanistic studies reveal that formation of a phenanthrolinyl-ligated gold(I) complex is crucial for the efficiency and selectivity of the target transformation.

Visible-light-activated copper(i) catalyzed oxidative Csp-Csp cross-coupling reaction: Efficient synthesis of unsymmetrical conjugated diynes without ligands and base

A novel visible-light-promoted copper-catalysed process for the Csp-Csp cross-coupling reaction of terminal alkynes at room temperature is described. The current photochemical method is simple, highly functional group compatible, and more viable towards the construction of bio-active 1,3-unsymmetrical conjugated diynes without the need of bases/ligands, additives and expensive palladium/gold catalysts.