116700-36-8 Usage
Description
H-9 DIHYDROCHLORIDE, also known as 9-(tetrahydro-2-furanyl)-9H-purin-6-amine dihydrochloride, is a synthetic compound with potent inhibitory properties against various protein kinases. It is a white crystalline solid that has been widely studied for its potential applications in the field of medicine and biochemistry.
Uses
Used in Pharmaceutical Industry:
H-9 DIHYDROCHLORIDE is used as a potent competitive inhibitor for protein kinase C, cGMP-, and cAMP-dependent protein kinase with respect to ATP. Its ability to inhibit these kinases makes it a valuable tool in the development of drugs targeting various diseases and conditions.
Used in Research and Development:
In the field of research, H-9 DIHYDROCHLORIDE is used as a research chemical to study the role of protein kinases in cellular processes. Its inhibitory properties allow scientists to investigate the effects of blocking these enzymes, which can provide insights into the development of new therapeutic strategies.
Used in Drug Discovery:
H-9 DIHYDROCHLORIDE is used as a starting point for the development of new drugs targeting protein kinases. Its chemical structure can be modified to create more specific and potent inhibitors, which can be used to treat various diseases, including cancer and other conditions involving abnormal cell signaling.
Used in Diagnostic Applications:
Due to its inhibitory properties, H-9 DIHYDROCHLORIDE can be used in the development of diagnostic tools to detect and monitor the activity of protein kinases. This can help in the early detection of diseases and the assessment of treatment efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 116700-36-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,6,7,0 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 116700-36:
(8*1)+(7*1)+(6*6)+(5*7)+(4*0)+(3*0)+(2*3)+(1*6)=98
98 % 10 = 8
So 116700-36-8 is a valid CAS Registry Number.
116700-36-8Relevant articles and documents
Unconventional Synthetic Process of Fasudil Hydrochloride: Costly Homopiperazine Was Avoided
Zhao, Jianhong,Wang, Dingding,Yang, Wu-Lin,Niu, Jinming,Wu, Weiting
, p. 91 - 96 (2021/12/06)
An efficient, robust, and cost-effective synthetic process of fasudil hydrochloride 1 was developed. Starting from readily available ethylenediamine and 5-isoquinoline sulfonyl chloride, the target product 1 was prepared through a six-step reaction, including sulfonamidation, protection, nucleophilic substitution, deprotection, cyclization, and salification. The process afforded 1 in 67.1% overall yield (based on 5-isoquinoline sulfonyl chloride) with 99.94% purity. Compared to the earlier published methodologies, the use of homopiperazine or its derivatives as intermediates was avoided. The salient features of this environmentally friendly synthetic route include easily available starting materials and operational simplicity, which could be suitable for large-scale industrial production.
