116795-55-2

Basic information

• Product Name: 1-(1-Trityl-1H-iMidazol-4-yl)-ethanone
• Synonyms: 1-(1-Trityl-1H-iMidazol-4-yl)-ethanone;1-[1-(triphenylMethyl)-1H-iMidazol-4-yl]ethan-1-one
• CAS NO: 116795-55-2
• Molecular Formula: C₂₄H₂₀N₂O
• Molecular Weight: 352.4284
• Mol File: 116795-55-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 507.2 °C at 760 mmHg
• Flash Point: 260.6 °C
• Appearance: /
• Density: 1.09 g/cm³
• Vapor Pressure: 2.07E-10mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(1-Trityl-1H-iMidazol-4-yl)-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Trityl-1H-iMidazol-4-yl)-ethanone(116795-55-2)
• EPA Substance Registry System: 1-(1-Trityl-1H-iMidazol-4-yl)-ethanone(116795-55-2)

Safety Data

• Hazardous Substances Data: 116795-55-2(Hazardous Substances Data)

Usage

Description

1-(1-Trityl-1H-imidazol-4-yl)-ethanone is an organic compound characterized by its trityl group attached to an imidazole ring, which is further connected to an ethanone moiety. This unique structure endows it with specific chemical properties that make it a valuable intermediate in various synthetic processes.

Uses

Used in Pharmaceutical Industry:
1-(1-Trityl-1H-imidazol-4-yl)-ethanone is used as a synthetic reactant for the preparation of Imidazolyl Benzothiophene derivatives, which are of interest in the development of new pharmaceutical agents due to their potential biological activities and therapeutic applications.
Used in Biochemical Research:
1-(1-Trityl-1H-imidazol-4-yl)-ethanone is utilized in the study of C17,20-lyase inhibitors, which are enzymes involved in the biosynthesis of steroid hormones. 1-(1-Trityl-1H-imidazol-4-yl)-ethanone serves as a valuable tool in understanding the enzyme's mechanism and structure, aiding in the design of more effective inhibitors for the treatment of hormone-related disorders.

InChI:InChI=1/C24H20N2O/c1-19(27)23-17-26(18-25-23)24(20-11-5-2-6-12-20,21-13-7-3-8-14-21)22-15-9-4-10-16-22/h2-18H,1H3

Upstream product

• 76-83-5 trityl chloride 
• 61985-25-9 1-(1H-imidazol-4-yl)ethan-1-one 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 62256-50-2 alpha-methyl-1-triphenylmethyl-1H-imidazole-4-methanol 
• 127607-72-1 ethyl 3-oxo-3-<1-(triphenylmethyl)-1H-imidazol-4-yl>propanoate 

Downstream Products

• 403792-81-4 4-(3-dimethylaminoprop-2-en-1-oyl)-1-triphenylmethylimidazole 
• 127607-73-2 (Z)-ethyl 2-methyl-3-<1-(triphenylmethyl)-1H-imidazol-4-yl>-2-butenoate 
• 116795-71-2 alpha-(6-chloro-2,2-dimethyl-4H-1,3-benzodioxin-8-yl)-alpha-methyl-1-triphenylmethyl-1H-imidazole-4-methanol 
• 176721-03-2 4-<1-(2,3-dimethylphenyl)-1-hydroxyethyl>-1-(triphenylmethyl)imidazole 
• 86347-14-0 medetomidine 
• 176721-04-3 (S)-dexmedetomidine-L-(+)-tartrate 
• 1571145-60-2 (E)-3-(dimethylamino)-1-(1-trityl-1H-imidazol-4-yl)prop-2-en-1-one 
• 337535-49-6 1-(4'-fluoro[1,1'-biphenyl]-3-yl)-1-(1-trityl-1H-imidazol-4-yl)-1-ethanol 
• 132287-48-0 4-(3,3-diphenylpropen-2-yl)-1H-imidazole 
• 106147-56-2 4-(1-Methyl-2,2-diphenyl-ethyl)-1H-imidazole 
• 106147-54-0 4-(1-Methyl-2,2-diphenyl-vinyl)-1H-imidazole 
• 138408-31-8 3-(1-Trityl-1H-imidazol-4-yl)-butyronitrile 
• 698367-52-1 ethyl 3-(1-triphenylmethyl-1H-imidazol-4-yl)butanoate 
• 496961-60-5 3-(1-triphenylmethyl-1H-imidazol-4-yl)butanal 

Relevant articles and documents

Method for preparing dexmedetomidine and intermediate thereof

The invention provides a method for preparing dexmedetomidine and an intermediate thereof. Specifically speaking, the method comprises the steps that a compound shown as a formula II (please see the formula in the description) reacts with metal magnesium to prepare a metal magnesium Grignard reagent, and then the metal magnesium Grignard reagent reacts with a compound shown as a formula III (please see the formula in the description). The process has the advantages of being few in step, high in yield, easy to operate, high in product purity and the like and is quite suitable for large-scale industrialized production.

PYRAZOLE DERIVATIVES AS CYTOCHROME P450 INHIBITORS

The present invention provides compounds of formula (I), or pharmaceutically acceptable salts or solvates thereof, methods for their preparation, methods for their use, and pharmaceutical formulations comprising them.

Imidazolo-5-YL-2anilino-pyrimidines as agents for the inhibition of the cell proliffration

Compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, p, q, and n are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.