62256-50-2

Basic information

• Product Name: 1-(1-Trityl-1H-iMidazol-4-yl)-ethanol
• Synonyms: 1-(1-Trityl-1H-iMidazol-4-yl)-ethanol;1-[1-(triphenylMethyl)-1H-iMidazol-4-yl]ethan-1-ol;1-[4-(N-Triphenylmethyl)imidazolyl]ethanol;4-(1-Hydroxyethyl)-1-triphenylmethylimidazole;alpha-Methyl-1-(triphenylmethyl)-1H-imidazole-4-methanol
• CAS NO: 62256-50-2
• Molecular Formula: C₂₄H₂₂N₂O
• Molecular Weight: 354.44428
• Mol File: 62256-50-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 516.269 °C at 760 mmHg
• Flash Point: 266.03 °C
• Appearance: /
• Density: 1.101 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 1-(1-Trityl-1H-iMidazol-4-yl)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Trityl-1H-iMidazol-4-yl)-ethanol(62256-50-2)
• EPA Substance Registry System: 1-(1-Trityl-1H-iMidazol-4-yl)-ethanol(62256-50-2)

Safety Data

• Hazardous Substances Data: 62256-50-2(Hazardous Substances Data)

Usage

General Description

1-(1-Trityl-1H-imidazol-4-yl)-ethanol is a chemical compound with the molecular formula C26H25N2O. It is an alcohol derivative with a trityl-protected imidazole group, making it a useful building block in organic synthesis. 1-(1-Trityl-1H-imidazol-4-yl)-ethanol is commonly used as a reagent in the production of various pharmaceuticals and agrochemicals. It is also used in the synthesis of peptide-based drugs and as a ligand in coordination chemistry. 1-(1-Trityl-1H-imidazol-4-yl)-ethanol has applications in the field of medicinal chemistry and is also being researched for its potential therapeutic properties.

InChI:InChI=1/C24H22N2O/c1-19(27)23-17-26(18-25-23)24(20-11-5-2-6-12-20,21-13-7-3-8-14-21)22-15-9-4-10-16-22/h2-19,27H,1H3

Upstream product

• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 
• 75-07-0 acetaldehyde 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 
• 76-83-5 trityl chloride 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 138408-31-8 3-(1-Trityl-1H-imidazol-4-yl)-butyronitrile 
• 138408-30-7 3-(1-Triphenylmethyl-1H-imidazol-4-yl)-2-butennitril 
• 698367-54-3 ethyl 3-(1-triphenylmethyl-1H-imidazol-4-yl)-3-methyl-2-propenoate 
• 116795-55-2 1-(1-triphenylmethyl-1H-imidazol-4-yl)-1-ethanone 

Relevant articles and documents

PYRAZOLE DERIVATIVES AS CYTOCHROME P450 INHIBITORS

The present invention provides compounds of formula (I), or pharmaceutically acceptable salts or solvates thereof, methods for their preparation, methods for their use, and pharmaceutical formulations comprising them.

Organic compounds

The present invention provides a compound of formula I: Said compound is inhibitor of aldosterone synthase and aromatase, and thus can be employed for the treatment of a disorder or disease mediated by aldosterone synthase or aromatase. Accordingly, the compound of formula I can be used in treatment of hypokalemia, hypertension, congestive heart failure, atrial fibrillation, renal failure, in particular, chronic renal failure, restenosis, atherosclerosis, syndrome X, obesity, nephropathy, post-myocardial infarction, coronary heart diseases, inflammation, increased formation of collagen, fibrosis such as cardiac or myocardiac fibrosis and remodeling following hypertension and endothelial dysfunction, gynecomastia, osteoporosis, prostate cancer, endometriosis, uterine fibroids, dysfunctional uterine bleeding, endometrial hyperplasia, polycystic ovarian disease, infertility, fibrocystic breast disease, breast cancer and fibrocystic mastopathy. Finally, the present invention also provides a pharmaceutical composition.

Imidazolo-5-YL-2anilino-pyrimidines as agents for the inhibition of the cell proliffration

Compounds of the formula (I): wherein R1, R2, R3, R4, R5, R6, p, q, and n are as defined within and a pharmaceutically acceptable salts and in vivo hydrolysable esters are described. Also described are processes for their preparation and their use as medicaments, particularly medicaments for producing a cell cycle inhibitory (anti-cell-proliferation) effect in a warm-blooded animal, such as man.