1173928-82-9

Basic information

• Product Name: N-(5-chloro-2-iodophenyl)-1H-indazole-3-carboxamide
• CAS NO: 1173928-82-9
• Molecular Weight: 397.602
• Mol File: 1173928-82-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(5-chloro-2-iodophenyl)-1H-indazole-3-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(5-chloro-2-iodophenyl)-1H-indazole-3-carboxamide(1173928-82-9)
• EPA Substance Registry System: N-(5-chloro-2-iodophenyl)-1H-indazole-3-carboxamide(1173928-82-9)

Safety Data

• Hazardous Substances Data: 1173928-82-9(Hazardous Substances Data)

Upstream product

• 6828-35-9 5-chloro-2-iodoaniline 
• 115660-68-9 diindazolo<2,3-a,2',3'-d>pyrazine-7,14-dione 

Relevant articles and documents

N-(indazolyl)benzamido derivatives as CDK1 inhibitors: Design, synthesis, biological activity, and molecular docking studies

A series of N-1H-indazole-1-carboxamides has been synthesized and their effects on both CDK1 / cyclin B and the K-562 (human chronic myelogenus leukemia) cell line were evaluated. Using a computational model, we have observed that all the most active compounds 9e, f, i-n exhibited the same binding mode of purvanalol A in the ATP-binding cleft. Although they were able to moderately inhibit the leukemic cell line K-562 and to show inhibitory activity against the Cdc2-Cyclin B kinase in the low micromolar range, they turned out to be non-cytotoxic against HuDe (IZSL) primary cell cultures from human derm. These preliminary results are quite encouraging in view of the low toxicity demonstrated by the above-mentioned compounds.