6828-35-9

Basic information

• Product Name: 5-CHLORO-2-IODOANILINE
• Synonyms: 2-AMINO-4-CHLORO-IODOBENZENE;5-CHLORO-2-IODO-PHENYLAMINE;5-CHLORO-2-IODOANILINE;5-Chloro-2-iodobenzenamine;BenzenaMine, 5-chloro-2-iodo-;5-Chloro-2-iodoanilline;5-Chloro-2-iodoaniline 97%
• CAS NO: 6828-35-9
• Molecular Formula: C₆H₅ClIN
• Molecular Weight: 253.47
• Product Categories: Anilines, Amides & Amines;Chlorine Compounds;Iodine Compounds;Amines;C2 to C6;Nitrogen Compounds
• Mol File: 6828-35-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 40-42°C
• Boiling Point: 295.8 °C at 760 mmHg
• Flash Point: 110 °C
• Appearance: /
• Density: 2.015g/cm³
• Vapor Pressure: 0.00149mmHg at 25°C
• Refractive Index: 1.694
• Storage Temp.: 2-8°C(protect from light)
• PKA: 1.48±0.10(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 5-CHLORO-2-IODOANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-IODOANILINE(6828-35-9)
• EPA Substance Registry System: 5-CHLORO-2-IODOANILINE(6828-35-9)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25-37/38-41-52/53
• Safety Statements: 26-36/37/39-45-61
• RIDADR: UN2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 6828-35-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C6H5ClIN/c7-4-1-2-5(8)6(9)3-4/h1-3H,9H2

Upstream product

• 108-42-9 3-chloro-aniline 
• 142-71-2 copper diacetate 
• 64-19-7 acetic acid 
• 6781-33-5 5-chloro-2-iodoaniline hydrochloride 
• 89-63-4 4-Chloro-2-nitroaniline 
• 5446-05-9 4-chloro-2-nitroiodobenzene 

Downstream Products

• 1006-99-1 2-methyl-5-chloro-benzothiazole 
• 274926-23-7 (5-chloro-2-iodo-phenyl)-(4-methoxybenzyl)-amine 
• 252349-70-5 (R)-2-(5-Chloro-2-iodo-phenylamino)-4-oxo-butyric acid (R)-1-isobutoxycarbonyl-ethyl ester 
• 857139-05-0 C₂₁⁽¹³⁾C₆H₂₉ClN₂O₅ 
• 857138-86-4 C₂₁⁽¹³⁾C₆H₃₀ClIN₂O₅ 
• 1173928-82-9 N-(5-chloro-2-iodophenyl)-1H-indazole-3-carboxamide 
• 252349-29-4 (+/-)-ethyl-2-(5-chloro-2-iodo-phenylamino)-4-oxo-butyrate 
• 105790-02-1 2-(2-bromo-phenylsulfanyl)-5-chloro-aniline 
• 1266329-34-3 5-chloro-2-{[2-(phenylethynyl)phenyl]ethynyl}aniline 
• 4926-65-2 5-chloro-2-phenyl-1H-benzimidazole 
• 15814-76-3 5-chloro-2-(1H-pyrrol-1-yl)aniline 
• 1410070-46-0 5-chloro-2-iodo-N-(4-iodophenyl)aniline 
• 1410070-92-6 5-chloro-2-iodo-N-phenylaniline 
• 57039-63-1 6-chloro-2-phenylindole 

Relevant articles and documents

Au-catalyzed formation of functionalized quinolines from 2-alkynyl arylazide derivatives

A new method for converting 2-alkynyl arylazide derivatives into functionalized polysubstituted quinolines following a gold-catalyzed 1,3-acetoxy shift/cyclization/1,2-group shift sequence has been developed. This transformation proceeds under mild reaction conditions, is efficient, and tolerates a large variety of functional groups.

Remarkable switch in the regiochemistry of the iodination of anilines by N-iodosuccinimide: Synthesis of 1,2-dichloro-3,4-diiodobenzene

Direct iodination of anilines by NIS in polar solvents (such as DMSO) affords p-iodinated products with up to >99% regioselectivity. Switching to less polar solvents (such as benzene) in the presence of AcOH inverts this outcome toward dramatically increased or preferential generation of the o-isomers, also with up to >99% regioselectivity. This finding was exploited in the synthesis of 1,2-dichloro-3,4-diiodobenzene. Georg Thieme Verlag Stuttgart - New York.

Gold-catalyzed transformation of 2-alkynyl arylazides: Efficient access to the valuable pseudoindoxyl and indolyl frameworks

An element of surprise: A series of functionalized 2-alkynyl arylazides has beed converted into 3-substituted indoles or 2,2-disubstituted indolin-3-ones in the presence of a gold(I) complex. Various oxygen or aryl nucleophiles can be used in this process to trap the intermediate α-imino gold carbene. The structural motifs of the products are found in a large variety of biologically active compounds and natural products. Copyright