118075-12-0

Basic information

• Product Name: 2'-hydroxy-4,4',6'-trimethoxymethoxylchalcone
• Synonyms: 2'-hydroxy-4,4',6'-trimethoxymethoxylchalcone
• CAS NO: 118075-12-0
• Molecular Weight: 404.417
• Mol File: 118075-12-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2'-hydroxy-4,4',6'-trimethoxymethoxylchalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-hydroxy-4,4',6'-trimethoxymethoxylchalcone(118075-12-0)
• EPA Substance Registry System: 2'-hydroxy-4,4',6'-trimethoxymethoxylchalcone(118075-12-0)

Safety Data

• Hazardous Substances Data: 118075-12-0(Hazardous Substances Data)

Upstream product

• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 
• 480-66-0 2,4,6-trihydroxyacetophenone 

Downstream Products

• 1202495-48-4 (2Z)-2-[3,4-bis(methoxymethoxy)benzylidene]-4,6-bis(methoxymethoxy)-1-benzofuran-3(2H)-one 
• 480-70-6 aureusidin 
• 143724-76-9 5-hydroxy-8-prenyl-3,4',7-tris-O-methoxymethylkaempferol 
• 216450-65-6 8-prenyl-3,7,4'-trihydroxy-5-methoxyflavone 
• 28610-31-3 8-prenylkaempferol 
• 28610-34-6 6,6-dimethyldihydropyran (2,3:7,8)-5,4'-dihydroxyflavonol 
• 1329801-99-1 3,5-hydroxy-4',7-dimethoxymethylflavone 
• 143724-66-7 3,4',7-tris-O-methoxymethylkaempferol 
• 143724-70-3 5-O-prenyl-3,7,4'-tris-O-methoxymethylkaempferol 
• 25515-46-2 2',4',6',4-tetrahydroxydihydrochalcone 
• 1072920-43-4 C₂₁H₂₄O₇ 

Relevant articles and documents

In Vitro Osteogenic Differentiation and Antibacterial Potentials of Chalcone Derivatives

Chalcone derivatives have been investigated as therapeutic agents for the anticancer, antioxidant, and anti-inflammatory fields. In this study, we have synthesized four different types of chalcone derivatives and demonstrated in vitro bioactivities. We divided these derivatives into two groups of chalcones on the basis of similar substituents on the aromatic rings, and we tested cell viability and proliferation potentials, which indicated that the methoxy substituent on the A ring could enhance cytotoxicity and antiproliferation potential depending on the chalcone concentration. We also investigated osteogenic differentiation of C2C12 cells by ALP staining, the early marker for osteogenesis, which demonstrated that the chalcones could not only induce activity of BMP-2 but also inhibit the activity of noggin, a BMP antagonist. In addition, chalcone bearing hydroxyl groups at the 2-, 4-, and 6-position on the A ring inhibited treptococcus mutans growth, a major causative agent of dental caries. Therefore, we concluded that the chalcone derivatives synthesized in this research can be good candidates for therapeutic agents promoting bone differentiation, with an expectation of inhibiting S. mutans, in dentistry.

The first total synthesis of sophoflavescenol, flavenochromane C, and citrusinol

The first total syntheses of sophoflavescenol (1), flavenochromane C (2), and citrusinol (3) were achieved. These three naturally occurring prenylated or prenyl-cyclized flavonoids have important biological activities such as cytotoxicity against some can