118545-50-9Relevant articles and documents
Folate-based inhibitors of thymidylate synthase: Synthesis and antitumor activity of γ-linked sterically hindered dipeptide analogues of 2-desamino- 2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)
Bavetsias, Vassilios,Jackman, Ann L.,Marriott, Jonathan H.,Kimbell, Rosemary,Gibson, William,Boyle, F. Thomas,Bisset, Graham M. F.
, p. 1495 - 1510 (2007/10/03)
In an effort to synthesize inhibitors of thymidylate synthase (TS) that do not undergo polyglutamation, a series of γ-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583) was pre
SYNTHESIS OF NONPROTEINOGENIC AMINO ACIDS PART 3: CONVERSION OF GLUTAMIC ACID INTO γ,δ-UNSATURATED α-AMINO ACIDS.
Baldwin, Jack E.,North, Michael,Flinn, Anthony,Moloney, Mark G.
, p. 1465 - 1474 (2007/10/02)
A general procedure for the asymmetric synthesis of γ,δ-unsaturated α-amino acids (7) from the γ-anion derived from (S)-glutamic acid is described.