118545-54-3

Basic information

• Product Name: t-butyl 2-tritylamino-4-carbomethoxy-5-hydroxy-(2S)-pentanoate
• Synonyms: t-butyl 2-tritylamino-4-carbomethoxy-5-hydroxy-(2S)-pentanoate
• CAS NO: 118545-54-3
• Molecular Weight: 489.612
• Mol File: 118545-54-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: t-butyl 2-tritylamino-4-carbomethoxy-5-hydroxy-(2S)-pentanoate(CAS DataBase Reference)
• NIST Chemistry Reference: t-butyl 2-tritylamino-4-carbomethoxy-5-hydroxy-(2S)-pentanoate(118545-54-3)
• EPA Substance Registry System: t-butyl 2-tritylamino-4-carbomethoxy-5-hydroxy-(2S)-pentanoate(118545-54-3)

Safety Data

• Hazardous Substances Data: 118545-54-3(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 118545-50-9 α-tert-butyl γ-methyl N-trityl-L-glutamate 
• 79640-72-5 L-glutamic acid 1-tert-butyl ester 5-methyl ester 
• 56-86-0 L-glutamic acid 
• 3077-51-8 γ-methyl L-glutamate hydrochloride 
• 76-83-5 trityl chloride 
• 34582-33-7 α-tert-butyl-γ-methyl L-Glu diester hydrochloride 

Downstream Products

• 125090-01-9 t-butyl 2-tritylamino-4-carboxy-5-hydroxy-(2S)-pentanoate 

Relevant articles and documents

SYNTHESIS OF NONPROTEINOGENIC AMINO ACIDS PART 2: PREPARATION OF A SYNTHETIC EQUIVALENT OF THE γ-ANION SYNTHON FOR ASYMMETRIC AMINO ACID SYNTHESIS

The synthesis of α-t-butyl γ-methyl N-trityl-(S)-glutamate (12) from (S)-glutamic acid (6) is described.Diester (12), on treatment with lithium isopropylcyclohexylamide followed by the addition of carbonyl compounds, reacts to give the γ-substituted glutamic acid derivatives (13a-i) with retention of optical purity at the α centre.