118715-16-5Relevant articles and documents
An intramolecular silyl transfer from the carboxylate to the hydroxyl group in sodium 4-hydroxybutyrate and its application to the synthesis of injectable antifungal posaconazole derivative, Sch 59884
Renton,Shen,Eckert,Lee,Gala,Chen,Pramanik,Schumacher
, p. 36 - 41 (2002)
Discovery of a novel intramolecular silyl group migration from a carboxylic acid to the hydroxyl group of sodium 4-hydroxybutyric acid, unraveling of its reaction mechanism and application of this finding to the synthesis of injectable antifungal Sch 59884 are described.
Synthetic studies toward cytostatin, a natural product inhibitor of protein phosphatase 2A
Salit, Anne-Frédérique,Meyer, Christophe,Cossy, Janine,Delouvrié, Bénédicte,Hennequin, Laurent
, p. 6684 - 6697 (2008/12/20)
Synthetic approaches toward the natural product cytostatin, an inhibitor of protein phosphatase 2A possessing cytotoxic and antimetastatic activities, have been investigated. A formal synthesis of cytostatin has been achieved according to a strategy relyi
Formal synthesis of cytostatin by a convergent approach
Salit, Anne-Frederique,Meyer, Christophe,Cossy, Janine
, p. 934 - 938 (2008/02/04)
A formal synthesis of cytostatin, an antitumor agent, has been achieved according to a convergent approach involving the coupling of a functionalized organolithium (C1-C8 subunit) with an aldehyde (C9-C13 subunit). Georg Thieme Verlag Stuttgart.
