118721-48-5

Basic information

• Product Name: 1-chloro-1-methylthio-1-(p-toluenesulfonyl)ethane
• Synonyms: 1-chloro-1-methylthio-1-(p-toluenesulfonyl)ethane
• CAS NO: 118721-48-5
• Molecular Weight: 264.797
• Mol File: 118721-48-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-chloro-1-methylthio-1-(p-toluenesulfonyl)ethane(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-1-methylthio-1-(p-toluenesulfonyl)ethane(118721-48-5)
• EPA Substance Registry System: 1-chloro-1-methylthio-1-(p-toluenesulfonyl)ethane(118721-48-5)

Safety Data

• Hazardous Substances Data: 118721-48-5(Hazardous Substances Data)

Upstream product

• 59662-65-6 methylthiomethyl p-tolyl sulfone 
• 94816-48-5 1-(methylthio)-1-(p-tolylsulfonyl)ethane 

Downstream Products

• 173959-53-0 2-[2-Chloro-2-methylsulfanyl-2-(toluene-4-sulfonyl)-ethyl]-malonic acid diethyl ester 
• 173959-52-9 2-[2-Methylsulfanyl-2-(toluene-4-sulfonyl)-ethyl]-malonic acid diethyl ester 
• 118721-49-6 1-(methylthio)-1-[(4-methylphenyl)sulfonyl]ethene 

Relevant articles and documents

Novel synthesis of γ-lactones starting from β,γ-unsaturated carboxylic esters

A novel synthetic route to highly substituted γ-lactones was achieved by an intermolecular radical addition to 4-(methylthio)-4-(p-tolylsulfonyl)-3-butenoic ester (1) and its 2-(ethoxycarbonyl) derivative (2), which were easily prepared from (methylthio)methyl p-tolyl sulfone. Upon the irradiation of a solution of 1 and benzophenone in an alcohol (R1R2CHOH), the 1-hydroxyalkyl radical (R1R2C-OH) was generated and added regiospecifically to the 3-position of 1 to form an adduct that led to a γ-lactone by spontaneous intramolecular condensation. Similarly, 2 reacted with the alcohol to give α-(ethoxycarbonyl)-γ-lactones. The alcohol, which is a high boiling liquid or solid, can be employed in the form of a solution (10 molar amounts in acetonitrile) without greatly lowering the reaction efficiency.