118721-49-6

Basic information

• Product Name: 1-(methylthio)-1-[(4-methylphenyl)sulfonyl]ethene
• Synonyms: 1-(methylthio)-1-[(4-methylphenyl)sulfonyl]ethene
• CAS NO: 118721-49-6
• Molecular Weight: 228.336
• Mol File: 118721-49-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-(methylthio)-1-[(4-methylphenyl)sulfonyl]ethene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(methylthio)-1-[(4-methylphenyl)sulfonyl]ethene(118721-49-6)
• EPA Substance Registry System: 1-(methylthio)-1-[(4-methylphenyl)sulfonyl]ethene(118721-49-6)

Safety Data

• Hazardous Substances Data: 118721-49-6(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 2949-92-0 methanethiosulfonic acid S-methyl ester 
• 31378-03-7 1-phenyl-2-tosylethanone 
• 94816-48-5 1-(methylthio)-1-(p-tolylsulfonyl)ethane 
• 59662-65-6 methylthiomethyl p-tolyl sulfone 
• 118721-48-5 1-chloro-1-methylthio-1-(p-toluenesulfonyl)ethane 

Downstream Products

• 1330533-10-2 1-methyl-3-methylthio-4-phenylnaphthalene 
• 875485-20-4 1-methyl-2-methylthio-4-phenylnaphthalene 
• 1330533-14-6 S-methyl 2-(benzoyl)thiobenzoate 
• 3795-79-7 methyl 4-(methylthio)benzoate 
• 173959-53-0 2-[2-Chloro-2-methylsulfanyl-2-(toluene-4-sulfonyl)-ethyl]-malonic acid diethyl ester 
• 201664-75-7 4-Methyl-N-[2-methylsulfanyl-2-(toluene-4-sulfonyl)-ethyl]-N-((E)-3-phenyl-allyl)-benzenesulfonamide 
• 173959-52-9 2-[2-Methylsulfanyl-2-(toluene-4-sulfonyl)-ethyl]-malonic acid diethyl ester 

Relevant articles and documents

Anticancer prodrug studies: DielsAlder chemistry of 1-methylthio-1-(p- tolylsulfonyl)ethene

The reactivity of 1-methylthio-1-(p-tolylsulfonyl)ethene (1) as a dienophile in DielsAlder chemistry is investigated. Cycloaddition reactions were carried out with a range of pyran-2-ones and isobenzofurans. The initial DielsAlder adducts have the potenti

Novel synthesis of γ-lactones starting from β,γ-unsaturated carboxylic esters

A novel synthetic route to highly substituted γ-lactones was achieved by an intermolecular radical addition to 4-(methylthio)-4-(p-tolylsulfonyl)-3-butenoic ester (1) and its 2-(ethoxycarbonyl) derivative (2), which were easily prepared from (methylthio)methyl p-tolyl sulfone. Upon the irradiation of a solution of 1 and benzophenone in an alcohol (R1R2CHOH), the 1-hydroxyalkyl radical (R1R2C-OH) was generated and added regiospecifically to the 3-position of 1 to form an adduct that led to a γ-lactone by spontaneous intramolecular condensation. Similarly, 2 reacted with the alcohol to give α-(ethoxycarbonyl)-γ-lactones. The alcohol, which is a high boiling liquid or solid, can be employed in the form of a solution (10 molar amounts in acetonitrile) without greatly lowering the reaction efficiency.