1187304-45-5

Basic information

• Product Name: 2-benzyl 7-methyl 3,4-dihydroisoquinoline-2,7(1H)-dicarboxylate
• Synonyms: 2-benzyl 7-methyl 3,4-dihydroisoquinoline-2,7(1H)-dicarboxylate
• CAS NO: 1187304-45-5
• Molecular Weight: 325.364
• Mol File: 1187304-45-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-benzyl 7-methyl 3,4-dihydroisoquinoline-2,7(1H)-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-benzyl 7-methyl 3,4-dihydroisoquinoline-2,7(1H)-dicarboxylate(1187304-45-5)
• EPA Substance Registry System: 2-benzyl 7-methyl 3,4-dihydroisoquinoline-2,7(1H)-dicarboxylate(1187304-45-5)

Safety Data

• Hazardous Substances Data: 1187304-45-5(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 220247-69-8 methyl 1,2,3,4-tetrahydroisoquinoline-7-carboxylate hydrochloride 

Downstream Products

• 877861-35-3 2-((benzyloxy)carbonyl)-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid 

Relevant articles and documents

APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF

The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).