220247-69-8 Usage
General Description
1,2,3,4-Tetrahydro-isoquinoline-7-carboxylic acid methyl ester HCL is a chemical compound that is synthesized by esterification of 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid with methanol in the presence of hydrochloric acid. It is a derivative of isoquinoline and has potential pharmacological applications, particularly in the development of neuroprotective and neuroregenerative drugs. 1,2,3,4-TETRAHYDRO-ISOQUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HCL has been studied for its potential as a treatment for neurodegenerative diseases, and it has shown promising results in preclinical trials. Additionally, it has been investigated for its potential as an inhibitor of acetylcholinesterase, an enzyme associated with Alzheimer's disease. Overall, 1,2,3,4-Tetrahydro-isoquinoline-7-carboxylic acid methyl ester HCL is a versatile chemical with potential pharmaceutical applications in the field of neurology.
Check Digit Verification of cas no
The CAS Registry Mumber 220247-69-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,0,2,4 and 7 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 220247-69:
(8*2)+(7*2)+(6*0)+(5*2)+(4*4)+(3*7)+(2*6)+(1*9)=98
98 % 10 = 8
So 220247-69-8 is a valid CAS Registry Number.
220247-69-8Relevant articles and documents
Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors
Wang, Zhen,Bian, Huan,Bartual, Sergio G.,Du, Wenting,Luo, Jinfeng,Zhao, Hu,Zhang, Shasha,Mo, Cheng,Zhou, Yang,Xu, Yong,Tu, Zhengchao,Ren, Xiaomei,Lu, Xiaoyun,Brekken, Rolf A.,Yao, Libo,Bullock, Alex N.,Su, Jin,Ding, Ke
supporting information, p. 5911 - 5916 (2016/07/06)
The structure-based design of 1, 2, 3, 4-tetrahydroisoquinoline derivatives as selective DDR1 inhibitors is reported. One of the representative compounds, 6j, binds to DDR1 with a Kd value of 4.7 nM and suppresses its kinase activity with an IC50 value of 9.4 nM, but it is significantly less potent for a panel of 400 nonmutated kinases. 6j also demonstrated reasonable pharmacokinetic properties and a promising oral therapeutic effect in a bleomycin-induced mouse pulmonary fibrosis model.
