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1188911-78-5

1188911-78-5

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1188911-78-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1188911-78-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,8,9,1 and 1 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1188911-78:
(9*1)+(8*1)+(7*8)+(6*8)+(5*9)+(4*1)+(3*1)+(2*7)+(1*8)=195
195 % 10 = 5
So 1188911-78-5 is a valid CAS Registry Number.

1188911-78-5Relevant articles and documents

4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors

Holladay, Mark W.,Campbell, Brian T.,Rowbottom, Martin W.,Chao, Qi,Sprankle, Kelly G.,Lai, Andiliy G.,Abraham, Sunny,Setti, Eduardo,Faraoni, Raffaella,Tran, Lan,Armstrong, Robert C.,Gunawardane, Ruwanthi N.,Gardner, Michael F.,Cramer, Merryl D.,Gitnick, Dana,Ator, Mark A.,Dorsey, Bruce D.,Ruggeri, Bruce R.,Williams, Michael,Bhagwat, Shripad S.,James, Joyce

, p. 5342 - 5346 (2011/10/09)

Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy) phenyl)urea hydrochloride) exhibits good pharmacokinetic properties in rat and mouse and is efficacious in a mouse tumor xenograft model following oral dosing.

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