577728-29-1

Basic information

• Product Name: 6-Ethoxy-7-Methoxyquinazoline-4-One
• Synonyms: 6-Ethoxy-7-Methoxyquinazoline-4-One;7-methoxy-6-ethoxyquinazoline-4-one;4(1H)-Quinazolinone,6-ethoxy-7-methoxy-(9CI)
• CAS NO: 577728-29-1
• Molecular Formula: C11H12N2O3
• Molecular Weight: 220.22458
• Product Categories: ETHOXY
• Mol File: 577728-29-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 383.418 °C at 760 mmHg
• Flash Point: 185.685 °C
• Appearance: /
• Density: 1.291 g/cm³
• PKA: 1.51±0.20(Predicted)
• CAS DataBase Reference: 6-Ethoxy-7-Methoxyquinazoline-4-One(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Ethoxy-7-Methoxyquinazoline-4-One(577728-29-1)
• EPA Substance Registry System: 6-Ethoxy-7-Methoxyquinazoline-4-One(577728-29-1)

Safety Data

• Hazardous Substances Data: 577728-29-1(Hazardous Substances Data)

Usage

General Description

6-Ethoxy-7-Methoxyquinazoline-4-One is a chemical compound with the molecular formula C11H10N2O3. It belongs to the quinazoline family and is characterized by the presence of an ethoxy group at the 6th position and a methoxy group at the 7th position of the quinazoline ring. 6-Ethoxy-7-Methoxyquinazoline-4-One has potential applications in the pharmaceutical industry due to its structural features, which are important for drug development. It may have biological activity and could be used as a building block in the synthesis of various pharmacologically active compounds. Further research is needed to fully understand the potential of 6-Ethoxy-7-Methoxyquinazoline-4-One and its possible uses in medicine and other fields.

Upstream product

• 74-96-4 ethyl bromide 
• 179688-52-9 6-hydroxy-7-methoxyquinazolin-4(3H)-one 
• 75-03-6 ethyl iodide 
• 50413-44-0 methyl 2-amino-5-hydroxy-4-methoxybenzoate 
• 215659-03-3 methyl 5-hydroxy-4-methoxy-2-nitrobenzoate 
• 77287-34-4 formamide 
• 214470-85-6 2-amino-5-ethoxy-4-methoxybenzoic acid methyl ester 
• 214470-90-3 5-ethoxy-4-methoxy-2-nitrobenzoic acid methyl ester 

Downstream Products

• 1188906-76-4 1-(5-tert-butylisoxazol-3-yl)-3-(3-(6-ethoxy-7-methoxyquinazolin-4-yloxy)phenyl)urea 
• 1188911-78-5 C₁₇H₁₇N₃O₃ 

Relevant articles and documents

4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors

Aryl phenyl ureas with a 4-quinazolinoxy substituent at the meta-position of the phenyl ring are potent inhibitors of mutant and wild type BRAF kinase. Compound 7 (1-(5-tert-butylisoxazol-3-yl)-3-(3-(6,7-dimethoxyquinazolin-4-yloxy) phenyl)urea hydrochloride) exhibits good pharmacokinetic properties in rat and mouse and is efficacious in a mouse tumor xenograft model following oral dosing.

QUINAZOLINE DERIVATIVES AS RAF KINASE MODULATORS AND METHODS OF USE THEREOF

Compounds according to formula (I), compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. Formula (I): or a pharmaceutically acceptable salt, solvate, clathrate of hydrate thereof, wherein X is O or S(O)t; Ra is O or S.