1189119-96-7

Basic information

• Product Name: (S)-2-(1-(4-fluorophenyl)ethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• Synonyms: (S)-2-(1-(4-fluorophenyl)ethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• CAS NO: 1189119-96-7
• Molecular Weight: 250.121
• Mol File: 1189119-96-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (S)-2-(1-(4-fluorophenyl)ethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(1-(4-fluorophenyl)ethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(1189119-96-7)
• EPA Substance Registry System: (S)-2-(1-(4-fluorophenyl)ethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(1189119-96-7)

Safety Data

• Hazardous Substances Data: 1189119-96-7(Hazardous Substances Data)

Upstream product

• 405-99-2 para-fluorostyrene 
• 73183-34-3 bis(pinacol)diborane 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 1416982-23-4 (S)-1-(4-fluorophenyl)-N,N,N-trimethylethanaminium trifluoromethanesulfonate 

Downstream Products

• 403-41-8 (S)-1-(4-fluorophenyl)ethan-1-ol 
• 403-41-8 (R)-1-(4-fluorophenyl)ethan-1-ol 

Relevant articles and documents

Nickel-Catalyzed Borylation of Benzylic Ammonium Salts: Stereospecific Synthesis of Enantioenriched Benzylic Boronates

We have developed a stereospecific, nickel-catalyzed cross-coupling of secondary benzylic ammonium salts and diboronate esters to deliver highly enantioenriched benzylic boronates. This reaction utilizes amine-derived electrophiles, which are readily available in high enantiopurity, and simple, inexpensive nickel catalysts. This reaction has broad scope, enabling synthesis of a variety of secondary benzylic boronates in good yields and excellent ee's.

Chiral 2-imidazoline aniline compound as well as preparation method and application thereof

The invention provides a chiral 2-imidazoline aniline compound as well as a preparation method and application thereof. The preparation method comprises the following steps: reacting an o-nitrobenzoic acid compound as shown in a formula (1), oxalyl chloride and N, N-dimethylformamide to obtain an o-nitrobenzoyl chloride compound as shown in a formula (7); adding the hydroxyl amide derivative into a mixed solution of an amino alcohol compound as shown in a formula (2) and triethylamine to obtain a hydroxyl amide derivative as shown in a formula (3); reacting with thionyl chloride to obtain a dichloro compound as shown in a formula (4); then adding triethylamine and primary amine R2NH2 to prepare a nitroimidazoline derivative; and finally, reducing to obtain the chiral 2-imidazoline aniline compound as shown in a formula (6). The chiral 2-imidazoline aniline compound is easy to prepare, the raw materials are cheap and easy to obtain, the preparation method is simple, and the synthesized chiral ligand containing the 2-imidazoline aniline fragment can be used as a catalyst for catalyzing asymmetric hydroboration reaction of cobalt-catalyzed olefin and asymmetric hydroamination reaction of cobalt-catalyzed non-activated terminal olefin.

Chiral quinoline amine compound and preparation method and application thereof

The invention discloses a chiral quinoline amine compound shown in a formula (1), and discloses a simple preparation method convenient to implement. The quinoline amine shown in the formula (1) can beused for preparing a chiral organic boron ester compound. A chiral oxazoline or imidazoline base quinoline amine compound and a transition metal MY'n in-situ complex can be adopted as a homogeneous catalyst, the catalyst is subjected to asymmetry hydroboration addition on carbon-carbon atom double bonds of the prochirality organic compound to be used for preparing the chiral organic boron compound, and the prochirality unsaturated compound for optimizing the asymmetric boron hydrogen effect is a styrene compound. The prepared chiral organic boron ester compound is an important organic synthesis midbody and is particularly applied to the production aspect of medicine preparations, spice, fumet and agricultural chemicals.