403-41-8

Basic information

• Product Name: 1-(4-Fluorophenyl)ethanol
• Synonyms: 4-fluoro-α-methylbenzyl alcohol;4-Fluoro-alpha-methylbenzyl alcohol 97%;4-Fluoro-alpha-methylbenzylalcohol97%;1-(p-Fluorophenyl)ethyl alcohol;4-Fluoro-α-methylbenzenemethanol;α-Methyl-4-fluorobenzenemethanol;α-Methyl-4-fluorobenzyl alcohol;4-Fluoro-alpha-methylbenzyl alcohol,99%
• CAS NO: 403-41-8
• Molecular Formula: C₈H₉FO
• Molecular Weight: 140.15
• EINECS: 206-959-3
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Fluorine Compounds;Phenols;Alcohols;C7 to C8;Oxygen Compounds;Fluorine series
• Mol File: 403-41-8.mol
• Article Data: 507

Chemical Properties

• Melting Point: 9 °C
• Boiling Point: 90-92 °C7 mm Hg(lit.)
• Flash Point: 195 °F
• Appearance: clear light yellow liquid
• Density: 1.109 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0829mmHg at 25°C
• Refractive Index: n20/D 1.501(lit.)
• Storage Temp.: 2-8°C
• PKA: 14.36±0.20(Predicted)
• CAS DataBase Reference: 1-(4-Fluorophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenyl)ethanol(403-41-8)
• EPA Substance Registry System: 1-(4-Fluorophenyl)ethanol(403-41-8)

Safety Data

• Hazard Codes: Xi,F,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 403-41-8(Hazardous Substances Data)

Usage

Chemical Properties

clear light yellow liquid

General Description

4-Fluoro-α-methylbenzyl alcohol was isolated as phytocomponent in the methanolic extracts of the whole plant of Thevetia peruviana.

InChI:InChI=1/C8H9FO/c1-6(10)7-2-4-8(9)5-3-7/h2-6,10H,1H3

Upstream product

• 917-64-6 methyl magnesium iodide 
• 459-57-4 4-fluorobenzaldehyde 
• 75-16-1 methylmagnesium bromide 
• 405-99-2 para-fluorostyrene 
• 107-03-9 1-thiopropane 
• 75-89-8 2,2,2-trifluoroethanol 
• 456-16-6 1-(1-chloroethyl)-4-fluorobenzene 
• 107-19-7 propargyl alcohol 
• 65130-46-3 1-(4-fluorophenyl)ethyl bromide 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 25015-63-8 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane 
• 75-24-1 trimethylaluminum 
• 456-04-2 2-Chloro-4'-fluoroacetophenone 
• 172585-57-8 (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester 

Downstream Products

• 456-16-6 1-(1-chloroethyl)-4-fluorobenzene 
• 2063-74-3 4,4'-(1,1'-oxybis(ethane-1,1-diyl))bis(fluorobenzene) 
• 65130-46-3 1-(4-fluorophenyl)ethyl bromide 
• 111662-72-7 1-(4-fluorophenyl)ethyl methyl ether 
• 111662-74-9 1-(4-fluorophenyl)ethyl ethyl ether 
• 31067-69-3 (p-fluorophenyl)methylcarbenium ion 
• 169301-03-5 2-Nitro-benzoic acid 1-(4-fluoro-phenyl)-ethyl ester 
• 403-41-8 (S)-1-(4-fluorophenyl)ethan-1-ol 
• 172585-57-8 (R)-acetic acid 1-(4-fluoro-phenyl)-ethyl ester 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 403-41-8 (R)-1-(4-fluorophenyl)ethan-1-ol 
• 1097209-11-4 C₂₆H₂₇ClF₂N₂O₂ 

Relevant articles and documents

N-Propylphthalimide-Substituted Silver(I) N-Heterocyclic Carbene Complexes and Ruthenium(II) N-Heterocyclic Carbene Complexes: Synthesis and Transfer Hydrogenation of Ketones

This study deals with the synthesis of N-propylphthalimide substituted Ag(I)-N-heterocyclic carbene (NHC) complexes and N-propylphthalimide substituted Ru(II)-NHC complexes in the transfer hydrogenation of ketones. The Ag(I)-NHC complexes were synthesized

Ru(ii)-N-heterocyclic carbene complexes: Synthesis, characterization, transfer hydrogenation reactions and biological determination

A series of ruthenium(ii) complexes with N-heterocyclic carbene ligands were successfully synthesized by transmetalation reactions between silver(i) N-heterocyclic carbene complexes and [RuCl2(p-cymene)]2 in dichloromethane under Ar

Nickel-Catalyzed Enantioselective Hydroboration of Vinylarenes

The enantioselective hydroboration of vinylarenes catalyzed by a chiral, nonracemic nickel catalyst is presented as a facile method for generating chiral benzylic boronate esters. Various vinylarenes react with bis(pinacolato)diboron (B2pin2) in the presence of MeOH as a hydride source to form chiral boronate esters in up to 92% yield with up to 94% ee. The use of anhydrous Me4NF to activate B2pin2 is crucial for ensuring fast transmetalation to achieve high enantioselectivities.

Visible-Light-Driven Catalytic Deracemization of Secondary Alcohols

Deracemization of racemic chiral compounds is an attractive approach in asymmetric synthesis, but its development has been hindered by energetic and kinetic challenges. Here we describe a catalytic deracemization method for secondary benzylic alcohols which are important synthetic intermediates and end products for many industries. Driven by visible light only, this method is based on sequential photochemical dehydrogenation followed by enantioselective thermal hydrogenation. The combination of a heterogeneous dehydrogenation photocatalyst and a chiral molecular hydrogenation catalyst is essential to ensure two distinct pathways for the forward and reverse reactions. These reactions convert a large number of racemic aryl alkyl alcohols into their enantiomerically enriched forms in good yields and enantioselectivities.