1189365-73-8

Basic information

• Product Name: quinolin-8-yl(4-(trifluoromethyl)phenyl)methanone
• Synonyms: quinolin-8-yl(4-(trifluoromethyl)phenyl)methanone
• CAS NO: 1189365-73-8
• Molecular Weight: 301.268
• Mol File: 1189365-73-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: quinolin-8-yl(4-(trifluoromethyl)phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: quinolin-8-yl(4-(trifluoromethyl)phenyl)methanone(1189365-73-8)
• EPA Substance Registry System: quinolin-8-yl(4-(trifluoromethyl)phenyl)methanone(1189365-73-8)

Safety Data

• Hazardous Substances Data: 1189365-73-8(Hazardous Substances Data)

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 16567-18-3 8-bromoquinoline 
• 38707-70-9 8-formylquinoline 
• 128796-39-4 4-trifluoromethylphenylboronic acid 
• 56234-20-9 1-(quinolin-8-yl)ethan-1-one 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 135-02-4 ortho-anisaldehyde 
• 98-80-6 phenylboronic acid 
• 1438559-01-3 (4-fluorophenyl)(quinolin-8-yl)methanone 
• 54885-04-0 phenyl(quinolin-8-yl)methanone 
• 40245-26-9 quinoline-8-carboxylic acid methyl ester 
• 86-59-9 8-carboxyquinoline 

Downstream Products

• 54885-04-0 phenyl(quinolin-8-yl)methanone 
• 1442660-26-5 (3,5-bis(trifluoromethyl)phenyl)(quinolin-8-yl)methanone 
• 1438559-01-3 (4-fluorophenyl)(quinolin-8-yl)methanone 
• 1438558-82-7 (3-methoxyphenyl)(quinolin-8-yl)methanone 
• 56234-20-9 1-(quinolin-8-yl)ethan-1-one 
• 20754-22-7 methyl (2E)-3-(4-(trifluoromethyl)phenyl)prop-2-enoate 
• 21469-76-1 (E)-N,N-dimethyl-3-(4-(trifluoromethyl)phenyl)prop-2-enamide 

Relevant articles and documents

Rhodium-Catalyzed Interconversion of Quinolinyl Ketones with Boronic Acids via C-C Bond Activation

A rhodium-catalyzed cross-coupling of aryl and aliphatic quinolinyl ketones with boronic acids has been developed. Proceeding via quinoline-directed carbon-carbon σ bond activation, the transformation demonstrates tolerance of a range of functional groups

Oxidative coupling of Michael acceptors with aryl nucleophiles produced through rhodium-catalyzed C-C bond activation

Utilizing rhodium catalysis, aryl nucleophiles generated via carbon-carbon single bond activation successfully undergo oxidative coupling with Michael acceptors. The reaction scope encompasses a broad range of nucleophiles generated from quinolinyl ketones as well as a series of electron deficient terminal alkenes, illustrating the broad potential of intersecting carbon-carbon bond activation with synthetically useful coupling methodologies. The demonstrated oxidative coupling produces a range of cinnamyl derivatives, several of which are challenging to prepare via conventional routes.