1442660-26-5

Basic information

• Product Name: (3,5-bis(trifluoromethyl)phenyl)(quinolin-8-yl)methanone
• Synonyms: (3,5-bis(trifluoromethyl)phenyl)(quinolin-8-yl)methanone
• CAS NO: 1442660-26-5
• Molecular Weight: 369.266
• Mol File: 1442660-26-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (3,5-bis(trifluoromethyl)phenyl)(quinolin-8-yl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3,5-bis(trifluoromethyl)phenyl)(quinolin-8-yl)methanone(1442660-26-5)
• EPA Substance Registry System: (3,5-bis(trifluoromethyl)phenyl)(quinolin-8-yl)methanone(1442660-26-5)

Safety Data

• Hazardous Substances Data: 1442660-26-5(Hazardous Substances Data)

Upstream product

• 54885-04-0 phenyl(quinolin-8-yl)methanone 
• 73852-19-4 3,5-bis-trifluromethylphenylboronic acid 
• 1189365-73-8 quinolin-8-yl(4-(trifluoromethyl)phenyl)methanone 
• 1438559-01-3 (4-fluorophenyl)(quinolin-8-yl)methanone 
• 98-80-6 phenylboronic acid 
• 16567-18-3 8-bromoquinoline 
• 135-02-4 ortho-anisaldehyde 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 56234-20-9 1-(quinolin-8-yl)ethan-1-one 
• 401-95-6 3,5-Bis(trifluoromethyl)benzaldehyde 
• 86-59-9 8-carboxyquinoline 
• 40245-26-9 quinoline-8-carboxylic acid methyl ester 

Downstream Products

• 705250-77-7 3-[3,5-bis(trifluoromethyl)phenyl]-2(Z)-propenoic acid methyl ester 

Relevant articles and documents

Oxidative coupling of Michael acceptors with aryl nucleophiles produced through rhodium-catalyzed C-C bond activation

Utilizing rhodium catalysis, aryl nucleophiles generated via carbon-carbon single bond activation successfully undergo oxidative coupling with Michael acceptors. The reaction scope encompasses a broad range of nucleophiles generated from quinolinyl ketones as well as a series of electron deficient terminal alkenes, illustrating the broad potential of intersecting carbon-carbon bond activation with synthetically useful coupling methodologies. The demonstrated oxidative coupling produces a range of cinnamyl derivatives, several of which are challenging to prepare via conventional routes.

Catalytic formation of ketones from unactivated esters through rhodium chelation-assisted C-O bond activation

A new method for building aryl aryl ketones containing heterocyclic rings through chelation-assisted C-O bond activation catalyzed by a rhodium complex has been developed. In this reaction, methyl quinoline-8-carboxylate, methyl quinoxaline-5-carboxylate, and their derivatives were reacted with an excess amount of a substituted phenyl boronic acid in the presence of a rhodium(I) complex to give substituted phenyl(quinolin-8-yl)methanone, phenylquinoxalin-5- ylmethanone, and their derivatives in medium to high yields. The current method offers a highly favorable synthetic pathway to efficiently build related drugs with an 8-benzoylquinoline core structure. This method may prove especially valuable for medicinal chemists for the late-stage introduction of versatile ketone moieties into complex scaffolds for diversity-oriented synthetic strategies.