119206-32-5

Basic information

• Product Name: C₁₉H₂₇NO₆
• Synonyms: C₁₉H₂₇NO₆
• CAS NO: 119206-32-5
• Molecular Weight: 365.426
• Mol File: 119206-32-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₇NO₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₇NO₆(119206-32-5)
• EPA Substance Registry System: C₁₉H₂₇NO₆(119206-32-5)

Safety Data

• Hazardous Substances Data: 119206-32-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 24608-52-4 tert-butyl chloroformate 

Downstream Products

• 66714-00-9 ethyl (tert-butoxycarbonyl)-L-phenylalanyl-L-phenylalaninate 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 140171-07-9 Boc-Phe-Phe-MePhe-Gly-Ψ(CH2-NH)-Leu-Met-NH2 
• 140170-93-0 Boc-Phe-Phe-Sar-Ψ(CH2-NH)-Leu-Met(O2)-NH2 
• 140171-06-8 Boc-Phe-MePhe-Gly-Ψ(CH2-NH)-Leu-Met-NH2 
• 140170-99-6 Boc-Phe-Val-Gly-Ψ(CH2-NH)-Leu-Nle-NH2 
• 140170-92-9 Boc-Phe-Sar-Ψ(CH2-NH)-Leu-Met(O2)-NH2 
• 70462-58-7 benzyl (tert-butoxycarbonyl)-L-phenylalanyl-L-prolinate 

Relevant articles and documents

Use of di-tert-butyl-dicarbonate both as a protecting and activating group in the synthesis of dipeptides

Amide formation from amino acids was achieved in an easy and convenient one-pot procedure using di-tert-butyl dicarbonate both as a protecting and an activating agent. A number of dipeptides have been synthesized in good yields. Copyright Taylor & Francis Group, LLC.

Synthesis and biological activities of neurokinin pseudopeptide analogues containing a reduced peptide bond

A series of pseudopeptides, analogues of neurokinin selective agonists, in which a peptide bond was replaced by a (CH2NH) bond were synthesized. The biological activities of these compounds were determined on selective pharmacological preparations: the dog carotid artery for NK-1, the rabbit pulmonary artery devoid of endothelium for the NK-2 and the rat portal vein for the NK-3 receptors. The results reported in this study indicate that insertion of a pseudopeptide bond in various positions of these selective agonists resulted in a great decrease in potency compared to the parent compounds. Furthermore, the selectivity of agonists is maintained by the use of a methylene amino group in position 9-10 (Sar) for the NK-1 or in position 7-8 (MePhe) for the NK-3 selective compound. The selectivity is greatly diminished for the NK-2 analogues.