119308-57-5

Basic information

• Product Name: Methyl 2,6-dibromopyridine-4-carboxylate
• Synonyms: Methyl 2,6-dibromopyridine-4-carboxylate;Methyl 2,6-dibromoisonicotinate;4-Pyridinecarboxylic acid, 2,6-dibroMo-, Methyl ester;6-dibroMopyridine-4-carboxylate;Methyl 2,6-dibromopyridine-4-carboxylate, 2,6-Dibromo-4-(methoxycarbonyl)pyridine
• CAS NO: 119308-57-5
• Molecular Formula: C₇H₅Br₂NO₂
• Molecular Weight: 294.93
• Mol File: 119308-57-5.mol
• Article Data: 23

Chemical Properties

• Melting Point: 86.8-88.2 °C(Solv: hexane (110-54-3))
• Boiling Point: 320.9°Cat760mmHg
• Flash Point: 147.9°C
• Appearance: /
• Density: 1.928g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -5.78±0.10(Predicted)
• CAS DataBase Reference: Methyl 2,6-dibromopyridine-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2,6-dibromopyridine-4-carboxylate(119308-57-5)
• EPA Substance Registry System: Methyl 2,6-dibromopyridine-4-carboxylate(119308-57-5)

Safety Data

• Hazardous Substances Data: 119308-57-5(Hazardous Substances Data)

Usage

General Description

Methyl 2,6-dibromopyridine-4-carboxylate is a chemical compound that belongs to the class of pyridine derivatives. It is a yellow crystalline solid with a molecular formula of C8H6Br2NO2. Methyl 2,6-dibromopyridine-4-carboxylate is commonly used in the field of organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and functional materials. Methyl 2,6-dibromopyridine-4-carboxylate is known for its high reactivity and versatility in chemical reactions, making it a valuable intermediate in the production of a wide range of compounds. However, it is important to handle this chemical with caution due to its potential health hazards and environmental impact.

InChI:InChI=1/C7H5Br2NO2/c1-12-7(11)4-2-5(8)10-6(9)3-4/h2-3H,1H3

Upstream product

• 99-11-6 citrazinic acid 
• 67-56-1 methanol 
• 2016-99-1 2,6-dibromoisonicotinic acid 

Downstream Products

• 1092771-12-4 methyl 2-bromo-6-(3'-methoxyphenylamino)isonicotinamide 
• 1196152-34-7 2 bromo-6-methoxy-pyridin-4-ylamine 
• 408352-56-7 C-(2,6-dibromo-[4]pyridyl)-methylamine 
• 1201675-41-3 4-(4-carbamoyl-2'-cyclohexylamino-3-phenyl-[2,4']bipyridinyl-6-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1201675-31-1 4-[2'-cyclohexylamino-4-(5-oxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl)-[2,4']bipyridinyl-6-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1201674-96-5 4-{4-carbamoyl-2'-[2-(4-hydroxyphenyl)ethylamino]-[2,4']bipyridinyl-6-yl}-piperazine-1-carboxylic acid tert-butyl ester 
• 1201674-94-3 4-[4-carbamoyl-2'-(3,4-dimethoxybenzylamino)-[2,4']bipyridinyl-6-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1201675-26-4 4-(2'-cyclohexylamino-4-hydrazinocarbonyl-[2,4']bipyridinyl-6-yl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1201675-54-8 4-[2'-cyclohexylamino-4-(1H-tetrazol-5-yl)-[2,4']bipyridinyl-6-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1201675-30-0 4-[2'-cyclohexylamino-4-(1-hydroxy-1-methylethyl)-[2,4']bipyridinyl-6-yl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1201673-93-9 2'-cyclohexylamino-3-phenyl-6-piperazin-1-yl-[2,4']bipyridinyl-4-carboxylic acid amide 
• 1201675-25-3 4-(2'-cyclohexylamino-4-[1,3,4]oxadiazol-2-yl-[2,4']bipyridinyl-6-yl)-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

"Super hybrid tridentate ligands": 4-substituted-2-(1-butyl-1H-1, 2,3-triazol-4-yl)-6-(1H-pyrazol-1-yl)pyridine ligands coordinated to Fe(ii) ions display above room temperature spin transitions

A series of novel "super hybrid tridentate ligands" based on (2-(1-butyl-1H-1,2,3-triazol-4-yl)-6-(1H-pyrazol-1-yl)pyridine (tpp) derivatives were synthesized. Their Fe(ii) complexes display around (T = 287 K) and above room temperature (T ? 375 K) spin transition temperatures.

6,6′-dibromo-4,4′-di(hexoxymethyl)-2,2′-bipyridine: A new solubilizing building block for macromolecular and supramolecular applications

Although brominated bipyridines and terpyridines are highly desirable synthetic building blocks for both ligand design and macro- or supramolecular applications, few such synthetic precursors have been reported that include much-needed solubilizing groups. Reported here is an inexpensive route to 2,6-dibromo-4-(hexoxymethyl)pyridine from citrazinic acid with an overall yield of 44% and its efficient conversion (60%) to 6,6′-dibromo-4,4′- di(hexoxymethyl)-2,2′-bipyridine via oxidative coupling.

Highly active electrocatalytic CO2 reduction with manganese N-heterocyclic carbene pincer by para electronic tuning

Electronic tuning by para substitutions was explored to achieve a highly active manganese N-heterocyclic carbene pincer complex for the selective electrocatalytic reduction of CO2 to CO. [MnCNCOMe]BF4 (L2-Mn) bearing an electron-donating group (–OMe) showed high activity with 63 × catalytic current enhancement, average Faradaic efficiency of 104%, and a TOFmax value of 26,127 s?1, which is 127 times higher than that of unsubstituted [MnCNCH]Br (L1-Mn) reported previously. In contrast, the electron-withdrawing group (–COOMe) in [MnCNCCOOMe]PF6 (L3-Mn) inhibited the electrocatalytic activity. Ambient Br?nstic acid, however, suppressed the activity of L2-Mn probably due to the protonation of the –OMe group. These findings indicate a potential electronic tuning strategy to improved manganese N-heterocyclic carbene catalysts for CO2 reduction.

METHOD FOR SYNTHESIZING ENANIOMERICALLY PURE N-(PYRIDIN-4-YL)-2-HYDROXY-ALKYLAMIDE DERIVATIVES

The present invention relates to a novel process for preparing enantiomerically pure compounds of N-(pyrid-4-yl)-2-hydroxyalkylamide type corresponding to the general formula (C) below: and also to processes for preparing the reaction intermediates used i