119615-63-3

Basic information

• Product Name: OLPRINONE HYDROCHLORIDE
• Synonyms: 3-pyridinecarbonitrile,1,2-dihydro-5-(imidazo(1,2-a)pyridin-6-yl)-6-methyl-2-o;e1020;xo-,monohydrochloride,monohydrate;OLPRINONE HCL;1,2-Dihydro-5-imidazo[1,2-α]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile Hydrochloride;Coretec;Loprinone hydrochloride, 1,2-Dihydro-5-(imidazo[1,2-a]pyridin-6-yl)-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride;3-Pyridinecarbonitrile,1,2-dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-,monohydrochloride
• CAS NO: 119615-63-3
• Molecular Formula: C14H10N4O.ClH.H2O
• Molecular Weight: 304.736
• Product Categories: Heterocyclic Compounds;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 119615-63-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: >3000C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: beige/solid
• Density: 1.34g/cm³
• Storage Temp.: 2-8°C
• Solubility: DMSO: ≤4 mg/mL
• CAS DataBase Reference: OLPRINONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: OLPRINONE HYDROCHLORIDE(119615-63-3)
• EPA Substance Registry System: OLPRINONE HYDROCHLORIDE(119615-63-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• RTECS: US4201450
• Hazardous Substances Data: 119615-63-3(Hazardous Substances Data)

Usage

Description

OLPRINONE HYDROCHLORIDE, also known as Coatec, is a potent and selective inhibitor of PDE III and a long-lasting, orally active, positive inotropic agent. It is an off-white crystalline powder that has been launched in Japan for acute cardiac insufficiency in cases resistant to other treatments. Its chemical properties and synthetic routes make it a promising pharmaceutical candidate for various applications in the medical field.

Uses

Used in Pharmaceutical Industry:
OLPRINONE HYDROCHLORIDE is used as an inotropic agent for the treatment of acute cardiac insufficiency in cases resistant to other treatments. It acts as a potent and selective inhibitor of PDE III, leading to increased levels of cAMP, which results in a positive inotropic effect that is not altered by β or H2-preceptor antagonists.
Used in Cardiovascular Applications:
OLPRINONE HYDROCHLORIDE is used as a cardiotonic agent to improve hemodynamic parameters with slight changes in heart rate and blood pressure. Its positive inotropic effect helps in the management of acute cardiac insufficiency and provides relief to patients with resistant cases.

Originator

Eisai (Japan)

InChI:InChI=1/C14H10N4O.ClH/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10;/h2-6,8H,1H3,(H,17,19);1H

Upstream product

• 106730-54-5 olprinone 
• 116355-08-9 1-imidazo<1,2-a>pyridin-6-yl-2-propanone 
• 116355-20-5 6-(2-methyl-2-propenyl)imidazo<1,2-a>pyridine 
• 6188-23-4 6-bromoimidazo[1,2-a]pyridine 

Relevant articles and documents

Olprinone hydrochloride compound preparation method

The invention discloses an olprinone hydrochloride compound preparation method. 6-bromoimidazo[1,2-a]pyridine is used as a starting material to prepare an olprinone hydrochloride compound through Grignard reaction, ozone oxidation, additive reaction, closed-loop reaction, salification and refining. The preparation process is mild in reaction condition, technically stable, high in repeatability andproduct yield, less in impurity and suitable for industrial production.