1196151-65-1Relevant articles and documents
Octupolar chimeric compounds built from quinoline caged acetate moieties: A novel approach for 2-photon uncaging of biomolecules
Picard, Sebastien,Genin, Emilie,Clermont, Guillaume,Hugues, Vincent,Mongin, Olivier,Blanchard-Desce, Mireille
, p. 3899 - 3913 (2013)
The present study describes the synthesis and investigation of chimeric structures where 6-quinoline and 8-quinoline caging units are integrated in multipolar systems to yield "hybrid" molecular structures for two-photon uncaging. These systems were demonstrated to exhibit strikingly enhanced (up to more than 2 orders of magnitude larger for octupolar derivatives) two-photon absorption responses in the NIR region compared to common caging groups. Whereas the quadrupolar compound shows the lowest two-photon uncaging cross-section (δu), octupolar chimeric derivatives display one-order larger δu values than their dipolar analogues. This opens a promising route for the design of efficient octupolar type derivatives for two-photon uncaging of biomolecules.
Quinoline-Derived Two-Photon-Sensitive Octupolar Probes
Dunkel, Petra,Petit, Morgane,Dhimane, Hamid,Blanchard-Desce, Mireille,Ogden, David,Dalko, Peter I.
, p. 660 - 667 (2017/10/23)
A systematic study on quinoline-derived light sensitive probes, having third-order rotational symmetry is presented. The electronically linked octupolar structures show considerably improved linear and nonlinear photophysical properties under one- and two-photon irradiation conditions compared to the corresponding monomers. Photolysis of the three acetate derivatives shows strong structure dependency: whereas irradiation of the 6- and 7-aminoquinoline derivatives resulted in fast intramolecular cyclization and only trace amounts of fragmentation products, the 8-aminoquinoline derivative afforded clean and selective photolysis, with a sequential release of their acetate groups (δu [730]=0.67 GM).
Design, synthesis and preliminary bioactivity evaluations of substituted quinoline hydroxamic acid derivatives as novel histone deacetylase (HDAC) inhibitors
Wang, Lei,Hou, Xuben,Fu, Huansheng,Pan, Xiaole,Xu, Wenfang,Tang, Weiping,Fang, Hao
, p. 4364 - 4374 (2015/08/03)
Inhibition of HDACs activity has become a promising therapeutic strategy in clinical practice to reverse the abnormal epigenetic states of cancer and other diseases. Therefore, HDAC inhibitors become a relatively new class of anti-cancer agent. In the present study, we reported the design and synthesis of a series of novel HDAC inhibitors using various substituted quinoline rings as the cap group. In vitro studies showed that some compounds have good inhibitory activities against HDACs and potent antiproliferative activities in some tumor cell lines. Especially, compound 9w (IC50 = 85 nM), exhibited better inhibitory effect compared with SAHA (IC50 = 161 nM).
