877-42-9

Basic information

• Product Name: 6-Bromo-2-methylquinoline
• Synonyms: 6-BROMO-2-METHYLQUINOLINE;6-BROMOQUINALDINE;6-BROMOQUINAIDINE;6-Bromoquinaldine, 6-Bromo-2-methyl-1-azanaphthalene;6-BroMo-2-Methylquinoline, 97+%;Quinoline, 6-bromo-2-methyl-;6-Bromoquildine, 98%
• CAS NO: 877-42-9
• Molecular Formula: C₁₀H₈BrN
• Molecular Weight: 222.08
• EINECS: -0
• Product Categories: Quinoline&Isoquinoline;Alkylquinolines;Haloquinolines;Quinolines;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;QuinolinesHeterocyclic Building Blocks
• Mol File: 877-42-9.mol
• Article Data: 47

Chemical Properties

• Melting Point: 101-105 °C(lit.)
• Boiling Point: 299.7 °C at 760 mmHg
• Flash Point: 135 °C
• Appearance: white to light yellow crystal powder
• Density: 1.488 g/cm³
• Vapor Pressure: 0.00209mmHg at 25°C
• Refractive Index: 1.654
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 5.02±0.43(Predicted)
• CAS DataBase Reference: 6-Bromo-2-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-2-methylquinoline(877-42-9)
• EPA Substance Registry System: 6-Bromo-2-methylquinoline(877-42-9)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-42-36/37/38-20/21/22
• Safety Statements: 26-39-36/37/39-24/25-22
• WGK Germany: 3
• Hazardous Substances Data: 877-42-9(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C10H8BrN/c1-7-2-3-8-6-9(11)4-5-10(8)12-7/h2-6H,1H3

Upstream product

• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 872-36-6 vinylene carbonate 
• 106-40-1 4-bromo-aniline 
• 5332-25-2 6-bromoquinoline 
• 78782-17-9 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane 
• 6563-11-7 6-bromoquinoline-N-oxide 
• 2065-66-9 methyl-triphenylphosphonium iodide 
• 64-19-7 acetic acid 
• 109-92-2 ethyl vinyl ether 
• 64-17-5 ethanol 
• 123-42-2 4-Hydroxy-4-methyl-2-pentanone 
• 29124-57-0 2-amino-5-bromobenzaldehyde 
• 1080-92-8 6-bromo-4-ethoxy-2-methyl-1,2,3,4-tetrahydro-quinoline 
• 50-00-0 formaldehyd 

Downstream Products

• 98948-91-5 6-bromoquinoline-2-carboxaldehyde 
• 83719-99-7 1-Phenyl-2-(6-bromo-2-quinolyl)ethanone 
• 1078-28-0 6-methoxyquinaldine 
• 35135-37-6 C₂₀H₂₀Br₂N₂ 
• 1020567-35-4 6-bromo-2-(tribromomethyl)quinoline 
• 91-63-4 2-methylquinoline 
• 1315248-52-2 2-methyl-6-trimethylsilanylethynylquinoline 
• 1315248-45-3 tris(2-methylquinolin-6-yl)amine 
• 1196151-65-1 (6-bromoquinolin-2-yl)methanol 
• 1315248-43-1 6-bromo-2-{[(tert-butyldimethylsilyl)oxy]methyl}quinoline 
• 1315248-44-2 tris(2-{[(tert-butyldimethylsilyl)oxy]methyl}quinolin-6-yl)amine 
• 1233505-71-9 6-ethynyl-2-methylquinoline 
• 1315248-53-3 tris[4-(2-methylquinolin-6-ylethynyl)phenyl]amine 
• 1315248-54-4 tris[4-(2-formylquinolin-6-ylethynyl)phenyl]amine 

Relevant articles and documents

Imaging of formaldehyde fluxes in epileptic brains with a two-photon fluorescence probe

A two-photon (TP) fluorescence probe has been developed for imaging endogenous FA fluxes during metabolic and epigenetic processes in animal models, especially in live brains.

Rhodium-Catalyzed C-H Annulation of Free Anilines with Vinylene Carbonate as a Bifunctional Synthon

Chemical transformation with vinylene carbonate as an emerging synthetic unit has recently attracted considerable attention. This report is a novel conversion pattern with vinylene carbonate, in which such a vibrant reagent unprecedentedly acts as a difunctional coupling partner to complete the C-H annulation of free anilines. From commercially available substrates, this protocol leads to the rapid construction of synthetically versatile 2-methylquinoline derivatives (43 examples) with excellent functionality tolerance.

A ortho position alkylation method of organic compound containg pyridine

A process for introducing alkyl at ortho positions of organic compounds containing pyridine. The method is not affected by the kind of substituent bonded to the pyridine and can be alkylated with high positional selectivity and high yield at N-based ortho-position of pyridine without being affected by the kind of substituent introduced to pyridine ortho position (pyridine N-based) can be advantageously used for the preparation of a compound containing an alkyl-introduced pyridine structure.

Nickel-Catalyzed Dehydrogenation of N-Heterocycles Using Molecular Oxygen

Herein, an efficient and selective nickel-catalyzed dehydrogenation of five- and six-membered N-heterocycles is presented. The transformation occurs in the presence of alkyl, alkoxy, chloro, free hydroxyl and primary amine, internal and terminal olefin, trifluoromethyl, and ester functional groups. Synthesis of an important ligand and the antimalarial drug quinine is demonstrated. Mechanistic studies revealed that the cyclic imine serves as the key intermediate for this stepwise transformation.