1201226-16-5 Usage
Description
(5-(Ethylamino)-5-oxopentyl)triphenylphosphonium bromide, also known as Bimatoprost Impurity 7, is a chemical compound derived from Bimatoprost (B386800), which is an antiglaucoma agent and a synthetic prostamide structurally related to prostaglandin F2α. (5-(ethylamino)-5-oxopentyl)triphenylphosphonium bromide possesses unique structural properties that differentiate it from the parent compound, Bimatoprost.
Uses
Used in Pharmaceutical Industry:
(5-(Ethylamino)-5-oxopentyl)triphenylphosphonium bromide is used as an impurity in the production of Bimatoprost, an antiglaucoma agent. Its presence in the manufacturing process of Bimatoprost is crucial for understanding the compound's overall effectiveness and safety profile. As an impurity, it may also provide insights into the development of new drugs or modifications to existing ones, potentially leading to improved treatment options for glaucoma patients.
Additionally, the study of Bimatoprost Impurity 7 can contribute to the broader understanding of the chemical properties and interactions of related compounds, which may have applications in other areas of pharmaceutical research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 1201226-16-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,0,1,2,2 and 6 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1201226-16:
(9*1)+(8*2)+(7*0)+(6*1)+(5*2)+(4*2)+(3*6)+(2*1)+(1*6)=75
75 % 10 = 5
So 1201226-16-5 is a valid CAS Registry Number.
1201226-16-5Relevant articles and documents
Synthesis of prostaglandin analogues, latanoprost and bimatoprost, using organocatalysis via a key bicyclic enal intermediate
Pr??vost, S??bastien,Thai, Karen,Sch??tzenmeister, Nina,Coulthard, Graeme,Erb, William,Aggarwal, Varinder K.
, p. 504 - 507 (2015)
Two antiglaucoma drugs, bimatoprost and latanoprost, which are analogues of the prostaglandin, PGF2?±, have been synthesized in just 7 and 8 steps, respectively. The syntheses employ an organocatalytic aldol reaction that converts succinaldehyde into a key bicyclic enal intermediate, which is primed for attachment of the required lower and upper side chains. By utilizing the crystalline lactone, the drug molecules were prepared in >99% ee.
Compound And Method
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Paragraph 0583-0590, (2015/06/17)
A compound of formula (I): (I) wherein Y is, Z is OR10, NR11R11 SR11, S(0)R11 S02R11, R10 is H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, CO—R11, or a protecting group, and R11 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, or alkoxyl; a process for making a compound of formula (I); and a process for making a prostaglandin or a prostaglandin analogue using a compound of formula (I). wherein Y is