1201795-29-0

Basic information

• Product Name: methyl tosyloxymethanephosphonate
• Synonyms: methyl tosyloxymethanephosphonate
• CAS NO: 1201795-29-0
• Molecular Weight: 280.238
• Mol File: 1201795-29-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl tosyloxymethanephosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl tosyloxymethanephosphonate(1201795-29-0)
• EPA Substance Registry System: methyl tosyloxymethanephosphonate(1201795-29-0)

Safety Data

• Hazardous Substances Data: 1201795-29-0(Hazardous Substances Data)

Upstream product

• 80792-13-8 dimethyl <<(p-tolylsulfonyl)oxy>methyl>phosphonate 
• 24630-67-9 hydroxymethyl-phosphonic acid dimethyl ester 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 854389-42-7 methyl (5'-O-dimethoxytrityl-3'-O-thymidinyl)methylphosphonate 
• 854389-55-2 [(2R,3R,5S)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxymethyl]-phosphonic acid monomethyl ester 

Relevant articles and documents

Methyl 4-toluenesulfonyloxymethylphosphonate, a new and versatile reagent for the convenient synthesis of phosphonate-containing compounds

A straightforward procedure leading to the new phosphonylating reagent, methyl 4-toluenesulfonyloxymethylphosphonate, requiring no chromatographic purification is described. This stable reagent works with the same efficiency as dimethyl and other dialkyl esters for the introduction of an O-phosphonomethyl moiety while, in contrast to dimethyl ester, it does not cause any unwanted methylation of sensitive functionalities. Its utility for the alkylation of protected nucleosides in high yield is exemplified.