854389-42-7

Basic information

• Product Name: methyl (5'-O-dimethoxytrityl-3'-O-thymidinyl)methylphosphonate
• Synonyms: methyl (5'-O-dimethoxytrityl-3'-O-thymidinyl)methylphosphonate
• CAS NO: 854389-42-7
• Molecular Weight: 652.638
• Mol File: 854389-42-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: methyl (5'-O-dimethoxytrityl-3'-O-thymidinyl)methylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (5'-O-dimethoxytrityl-3'-O-thymidinyl)methylphosphonate(854389-42-7)
• EPA Substance Registry System: methyl (5'-O-dimethoxytrityl-3'-O-thymidinyl)methylphosphonate(854389-42-7)

Safety Data

• Hazardous Substances Data: 854389-42-7(Hazardous Substances Data)

Upstream product

• 1201795-29-0 methyl tosyloxymethanephosphonate 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 50-89-5 thymidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 80792-13-8 dimethyl <<(p-tolylsulfonyl)oxy>methyl>phosphonate 

Relevant articles and documents

Inhibition of human thymidine phosphorylase by conformationally constrained pyrimidine nucleoside phosphonic acids and their "open-structure" isosteres

A series of conformationally constrained uridine-based nucleoside phosphonic acids containing annealed 1,3-dioxolane and 1,4-dioxane rings and their "open-structure" isosteres were synthesized and evaluated as potential multisubstrate-like inhibitors of t

Nucleosidyl-O-methylphosphonates: A pool of monomers for modified oligonucleotides

An unique set of 5′-O- and 3′-O-phosphonomethyl derivatives of four natural 2′-deoxyribonucleosides, 1-(2-deoxy-β-D-threo- pentofuranosyl)thymine, 5′-O- and 2′-O-phosphonomethyl derivatives of 1-(3-deoxy-β-D-erythro-pentofuranosyl)thymine, and 1-(3-deoxy-β-D- threo-pentofuranosyl)thymine has been synthesized as a pool of monomers for the synthesis of modified oligonucleotides. The phosphonate moiety was protected with 4-methoxy-1-oxido-2-pyridylmethyl ester group, serving also as an intramolecular catalyst in the coupling step.