1201943-62-5

Basic information

• Product Name: 1-TERT-BUTOXYCARBONYLAMINO-2-VINYL-CYCLOPROPANECARBOXYLIC ACID METHYL ESTER
• Synonyms: 1-Tert-Butoxycarbonylamino-2-Vinyl-Cyclopropanecarboxylic Acid Methyl Ester(WX665046)
• CAS NO: 1201943-62-5
• Molecular Formula: C12H19NO4
• Molecular Weight: 241.28356
• Mol File: 1201943-62-5.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-TERT-BUTOXYCARBONYLAMINO-2-VINYL-CYCLOPROPANECARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TERT-BUTOXYCARBONYLAMINO-2-VINYL-CYCLOPROPANECARBOXYLIC ACID METHYL ESTER(1201943-62-5)
• EPA Substance Registry System: 1-TERT-BUTOXYCARBONYLAMINO-2-VINYL-CYCLOPROPANECARBOXYLIC ACID METHYL ESTER(1201943-62-5)

Safety Data

• Hazardous Substances Data: 1201943-62-5(Hazardous Substances Data)

Usage

Derivative of cyclopropanecarboxylic acid

This compound is derived from cyclopropanecarboxylic acid, which is a carboxylic acid with a cyclopropane ring.

tert-Butoxycarbonyl-protected amine group

The compound contains an amine group (-NH-) that is protected by a tert-butoxycarbonyl group (-OC(CH3)3), which helps to prevent unwanted reactions with the amine group.

Vinyl group

The compound also contains a vinyl group (-CH=CH2), which is a carbon-carbon double bond that can participate in various chemical reactions.

Use as an intermediate in organic synthesis

This compound is often used as an intermediate in the synthesis of more complex organic compounds, particularly in the production of pharmaceuticals and agrochemicals.

Ability to undergo various chemical reactions

Due to the presence of the vinyl group and the protected amine group, this compound can undergo a variety of chemical reactions to form new compounds with different properties and uses.

Health and safety risks

It is important to handle this compound with care, as it may pose health and safety risks if not handled properly. This includes taking appropriate precautions to avoid exposure to the compound, as well as proper storage and disposal procedures.

Upstream product

• 159622-08-9 (1S,2S)-1-Azidocarbonyl-2-vinyl-cyclopropanecarboxylic acid methyl ester 
• 75-65-0 tert-butyl alcohol 
• 159622-09-0 (1R,2S)-1-tert-butoxycarbonylamino-2-vinyl-cyclopropanecarboxylic acid methyl ester 
• 6974-12-5 1,4-dibromo-2-butene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 66646-88-6 (E)-N-benzylideneglycine methyl ester 
• 213316-32-6 rac-(1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid ethyl ester 
• 67-56-1 methanol 
• 213316-49-5 (1RS,2SR)-ethyl 2-vinyl-1-(tert-butoxycarbonylamino)cyclopropanecarboxylate 
• 1201943-62-5 1-tert-butoxycarbonylamino-2-vinylcyclopropanecarboxylic acid methyl ester 
• 259214-55-6 (1S,2R)-1-tert-butoxycarbonylamino-2-vinylcyclopropanecarboxylic acid 
• 186581-53-3 diazomethane 
• 681260-04-8 (1R,2S)-1-amino-2-vinyl-cyclopropyl carboxylic acid methyl ester 
• 159622-10-3 (1R,2S)-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylic acid 

Downstream Products

• 159622-09-0 (1R,2S)-1-tert-butoxycarbonylamino-2-vinyl-cyclopropanecarboxylic acid methyl ester 
• 259214-55-6 (1S,2R)-1-tert-butoxycarbonylamino-2-vinylcyclopropanecarboxylic acid 
• 1201943-62-5 (1S,2R)-1-tert-butoxycarbonylamino-2-vinylcyclopropanecarboxylic acid methyl ester 
• 1201943-62-5 (1R,2R)-methyl 1-t-butoxycarbonylamino-2-vinylcyclopropane carboxylate 
• 853269-57-5 tert-butyl [(1R,2S)-2-ethenyl-1-{[(1-methylcyclopropyl)sulfonyl]carbamoyl}cyclopropyl]carbamate 

Relevant articles and documents

Enantioselective synthesis of (1R,2S) and (1S,2S) dehydrocoronamic acids

Thanks to the successive use of two esterases with different regioselectivities and conventional organic chemistry we have synthesized (1R,2S) and (1S,2S) dehydrocoronamic acids.

Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base

Asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid (vinyl-ACCA) is in extremely high demand due to the pharmaceutical importance of this tailor-made, sterically constrained α-amino acid. Here we report the development of an advanced procedure for preparation of the target amino acid via two-step SN2 and SN2′ alkylation of novel axially chiral nucleophilic glycine equivalent. Excellent yields and diastereoselectivity coupled with reliable and easy scalability render this method of immediate use for practical synthesis of (1R,2S)-vinyl-ACCA.

A TEIXOBACTIN ANALOGUE AND USE THEREOF

Provided herein belongs to the field of pharmaceuticals, and specifically relates to a Teixobactin analogue and use thereof. It further relates to a pharmaceutical composition comprising the compound and use of the compound and the pharmaceutical composit

Synthesis of methyl-1-(tert -butoxycarbonylamino)-2- vinylcyclopropanecarboxylate via a hofmann rearrangement utilizing trichloroisocyanuric acid as an oxidant

A trichloroisocyanuric acid (TCCA) mediated Hofmann rearrangement was utilized to synthesize methyl-1-(tert-butoxycarbonylamino)-2- vinylcyclopropanecarboxylate. A variety of functional groups are tolerated in this reaction including vinyl, cyclopropyl, pyridyl, aryl, benzyl, and nitro groups.